Keito Hoshitsuki
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Explore the profile of Keito Hoshitsuki including associated specialties, affiliations and a list of published articles.
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18
Citations
392
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Recent Articles
1.
Bhingarkar A, Wang Y, Hoshitsuki K, Eichinger K, Rathod S, Zhu Y, et al.
Front Pharmacol
. 2025 Jan;
15:1397995.
PMID: 39850568
Introduction: TNFα inhibitor (TNFi) immunogenicity in rheumatoid arthritis (RA) is a major obstacle to its therapeutic effectiveness. Although methotrexate (MTX) can mitigate TNFi immunogenicity, its adverse effects necessitate alternative strategies....
2.
Clinical Actionability of the NUDT15 *4 (p.R139H) Allele and Its Association With Hispanic Ethnicity
Maillard M, Nguyen J, Yang W, Hoshitsuki K, Relling M, Caudle K, et al.
Clin Pharmacol Ther
. 2024 Dec;
117(3):724-731.
PMID: 39688234
Nudix hydrolase 15 (NUDT15) deficiency is strongly associated with thiopurine-induced myelosuppression. Currently, testing for NUDT15 deficiency is based on the genotyping of the most frequent and clinically characterized no-function variants,...
3.
Rathod S, Hoshitsuki K, Zhu Y, Ramsey M, Fernandez C
Front Immunol
. 2024 Apr;
15:1392099.
PMID: 38686384
Background: Asparaginase (ASNase) is a crucial part of acute leukemia treatment, but immune responses to the agent can reduce its effectiveness and increase the risk of relapse. Currently, no reliable...
4.
Maillard M, Nishii R, Yang W, Hoshitsuki K, Chepyala D, Lee S, et al.
J Natl Cancer Inst
. 2024 Jan;
116(5):702-710.
PMID: 38230823
Background: Thiopurines such as mercaptopurine (MP) are widely used to treat acute lymphoblastic leukemia (ALL). Thiopurine-S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) inactivate thiopurines, and no-function variants are associated with...
5.
Hoshitsuki K, Zhou Y, Miller A, Choi J, Swanson H, Bhakta N, et al.
Leukemia
. 2023 Aug;
37(9):1782-1791.
PMID: 37543655
Polyethylene glycol (PEG)-asparaginase (pegaspargase) is a key agent in chemotherapy for acute lymphoblastic leukemia (ALL), but recipients frequently experience allergic reactions. We hypothesized that by decreasing antibody-producing CD20-positive B cells,...
6.
Yang W, Karol S, Hoshitsuki K, Lee S, Larsen E, Winick N, et al.
JAMA Netw Open
. 2022 Dec;
5(12):e2248803.
PMID: 36580335
Importance: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Hepatotoxic effects, including hyperbilirubinemia and elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, are common during all phases...
7.
Scott E, Yang Y, Botton M, Seki Y, Hoshitsuki K, Harting J, et al.
Hum Mutat
. 2022 Sep;
43(11):1557-1566.
PMID: 36057977
To determine the phase of NUDT15 sequence variants for more comprehensive star (*) allele diplotyping, we developed a novel long-read single-molecule real-time HiFi amplicon sequencing method. A 10.5 kb NUDT15...
8.
Kumar G, Hoshitsuki K, Rathod S, Ramsey M, Kokai L, Kershaw E, et al.
Acta Pharm Sin B
. 2022 Jan;
11(12):3779-3790.
PMID: 35024306
PEGylated-l-asparaginase (PEG-ASNase) is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). Its use is avoided in adults due to its high risk of liver injury including hepatic...
9.
Bhingarkar A, Vangapandu H, Rathod S, Hoshitsuki K, Fernandez C
Front Oncol
. 2021 Jul;
11:694526.
PMID: 34277440
Amino acid (AA) metabolism plays an important role in many cellular processes including energy production, immune function, and purine and pyrimidine synthesis. Cancer cells therefore require increased AA uptake and...
10.
Hoshitsuki K, Fernandez C, Yang J
J Clin Pharmacol
. 2021 Jun;
61 Suppl 1:S188-S192.
PMID: 34185912
Pharmacogenomics research ranges from the discovery of genetic factors to explain interpatient variability in drug exposure and response to clinical implementation of this knowledge to improve pharmacotherapy. Medications with actionable...