Takaya Moriyama
Overview
Explore the profile of Takaya Moriyama including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
30
Citations
869
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Escherich C, Moriyama T, Li Z, Hsiao Y, Hsiao Y, Yang W, et al.
Blood
. 2025 Jan;
145(11):1182-1194.
PMID: 39791601
Inotuzumab ozogamicin (InO) is an antibody-calicheamicin conjugate with striking efficacy in B-cell acute lymphoblastic leukemia (B-ALL). However, there is wide interpatient variability in treatment response, and the genetic basis of...
2.
Zinzani P, Izutsu K, Mehta-Shah N, Barta S, Ishitsuka K, Cordoba R, et al.
Lancet Oncol
. 2024 Nov;
25(12):1602-1613.
PMID: 39486433
Background: Peripheral T-cell lymphomas are aggressive non-Hodgkin lymphomas with few treatment options for relapsed or refractory disease. Valemetostat tosylate (valemetostat) is a potent, novel, dual inhibitor of EZH2 and EZH1....
3.
Li Y, Moriyama T, Yoshimura S, Zhao X, Li Z, Yang X, et al.
Sci Adv
. 2022 Dec;
8(50):eadd6403.
PMID: 36516256
Blinatumomab is an efficacious immunotherapeutic agent in B cell acute lymphoblastic leukemia (B-ALL). However, the pharmacogenomic basis of leukemia response to blinatumomab is unclear. Using genome-wide CRISPR, we comprehensively identified...
4.
Scott E, Yang Y, Botton M, Seki Y, Hoshitsuki K, Harting J, et al.
Hum Mutat
. 2022 Sep;
43(11):1557-1566.
PMID: 36057977
To determine the phase of NUDT15 sequence variants for more comprehensive star (*) allele diplotyping, we developed a novel long-read single-molecule real-time HiFi amplicon sequencing method. A 10.5 kb NUDT15...
5.
Yoshida M, Brown S, Moriyama T, Nishii R, Tsujimoto S, Yamada Y, et al.
Br J Haematol
. 2022 Jul;
199(2):270-276.
PMID: 35905175
6-Mercaptopurine (6-MP) is widely used for the treatment of paediatric leukaemia and lymphoma. Recently, germline variants in the NUDT15 gene have been identified as one of the major genetic causes...
6.
Fan P, Leung K, Chan K, Leung A, Lam G, Chow T, et al.
Pediatr Hematol Oncol
. 2021 Oct;
39(3):254-266.
PMID: 34665987
Inter-individual variance in 6-mercaptopurine (6-MP) dose intensity is common in patients with acute lymphoblastic leukemia (ALL). We aimed to evaluate the association of common variants of , , , and...
7.
Yoshida M, Nakabayashi K, Yang W, Sato-Otsubo A, Tsujimoto S, Ogata-Kawata H, et al.
Blood Adv
. 2021 Oct;
5(23):5420-5428.
PMID: 34662904
The effect of genetic variation on second malignant neoplasms (SMNs) remains unclear. First, we identified the pathogenic germline variants in cancer-predisposing genes among 15 children with SMNs after childhood leukemia/lymphoma...
8.
Somazu S, Tanaka Y, Tamai M, Watanabe A, Kagami K, Abe M, et al.
J Cell Mol Med
. 2021 Oct;
25(22):10521-10533.
PMID: 34636169
In chemotherapy for childhood acute lymphoblastic leukaemia (ALL), maintenance therapy consisting of oral daily mercaptopurine and weekly methotrexate is important. NUDT15 variant genotype is reportedly highly associated with severe myelosuppression...
9.
Moriyama T, Yang W, Smith C, Pui C, Evans W, Relling M, et al.
Pharmacogenet Genomics
. 2021 Aug;
32(2):60-66.
PMID: 34412101
Thiopurines [e.g. 6-mercaptopurine (6MP)] are essential for the cure of acute lymphoblastic leukemia (ALL) but can cause dose-limiting hematopoietic toxicity. Germline variants in drug-metabolizing enzyme genes TPMT and NUDT15 have...
10.
Nishii R, Mizuno T, Rehling D, Smith C, Clark B, Zhao X, et al.
Nat Commun
. 2021 Jul;
12(1):4181.
PMID: 34234136
Nucleobase and nucleoside analogs (NNA) are widely used as anti-viral and anti-cancer agents, and NNA phosphorylation is essential for the activity of this class of drugs. Recently, diphosphatase NUDT15 was...