Keith Rickert
Overview
Explore the profile of Keith Rickert including associated specialties, affiliations and a list of published articles.
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25
Citations
367
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Recent Articles
1.
Hutchinson M, Ruffolo J, Haskins N, Iannotti M, Vozza G, Pham T, et al.
MAbs
. 2024 Jun;
16(1):2362775.
PMID: 38899735
Over the past two decades, therapeutic antibodies have emerged as a rapidly expanding domain within the field of biologics. tools that can streamline the process of antibody discovery and optimization...
2.
Dippel A, Gallegos A, Aleti V, Barnes A, Chen X, Christian E, et al.
MAbs
. 2022 Dec;
15(1):2152526.
PMID: 36476037
To combat the COVID-19 pandemic, potential therapies have been developed and moved into clinical trials at an unprecedented pace. Some of the most promising therapies are neutralizing antibodies against SARS-CoV-2....
3.
St Amant A, Huang F, Lin J, Rickert K, Oganesyan V, Lemen D, et al.
Angew Chem Int Ed Engl
. 2019 Apr;
58(25):8489-8493.
PMID: 31018033
Here, we describe a diene-containing noncanonical amino acid (ncAA) capable of undergoing fast and selective normal electron-demand Diels-Alder (DA) reactions following its incorporation into antibodies. A cyclopentadiene derivative of lysine...
4.
Chen F, Ma K, Madajewski B, Zhuang L, Zhang L, Rickert K, et al.
Nat Commun
. 2018 Oct;
9(1):4141.
PMID: 30297810
Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking...
5.
Su H, Rickert K, Burlein C, Narayan K, Bukhtiyarova M, Hurzy D, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(3):E297-E306.
PMID: 28039433
Current therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against pain. Although originally identified as an oncogene, Tropomyosin-related kinase A...
6.
Tsui P, Higazi D, Wu Y, Dunmore R, Solier E, Kasali T, et al.
MAbs
. 2016 Nov;
9(1):104-113.
PMID: 27834568
Excessive transforming growth factor (TGF)-β is associated with pro-fibrotic responses in lung disease, yet it also plays essential roles in tissue homeostasis and autoimmunity. Therefore, selective inhibition of excessive and...
7.
Wang Q, Chang C, Pennini M, Pelletier M, Rajan S, Zha J, et al.
J Infect Dis
. 2016 Jan;
213(11):1800-8.
PMID: 26768253
The increasing incidence of Klebsiella pneumoniae infections refractory to treatment with current broad-spectrum antibiotic classes warrants the exploration of alternative approaches, such as antibody therapy and/or vaccines, for prevention and...
8.
Stachel S, Sanders J, Henze D, Rudd M, Su H, Li Y, et al.
J Med Chem
. 2014 Jun;
57(13):5800-16.
PMID: 24914455
We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from...
9.
Dudkin V, Rickert K, Kreatsoulas C, Wang C, Arrington K, Fraley M, et al.
Bioorg Med Chem Lett
. 2012 Mar;
22(7):2609-12.
PMID: 22374217
Pyridyl aminothiazoles comprise a novel class of ATP-competitive Chk1 inhibitors with excellent inhibitory potential. Modification of the core with ethylenediamine amides provides compounds with low picomolar potency and very high...
10.
Dudkin V, Wang C, Arrington K, Fraley M, Hartman G, Stirdivant S, et al.
Bioorg Med Chem Lett
. 2012 Feb;
22(7):2613-9.
PMID: 22365762
Translation of significant biochemical activity of pyridyl aminothiazole class of Chk1 inhibitors into functional CEA potency required analysis and adjustment of both physical properties and kinase selectivity profile of the...