Keith N Leppard
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Explore the profile of Keith N Leppard including associated specialties, affiliations and a list of published articles.
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19
Citations
373
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Recent Articles
1.
Moller-Olsen C, Ross T, Leppard K, Foisor V, Smith C, Grammatopoulos D, et al.
Sci Rep
. 2020 Jun;
10(1):8903.
PMID: 32483257
Bacterial neonatal meningitis results in high mortality and morbidity rates for those affected. Although improvements in diagnosis and treatment have led to a decline in mortality rates, morbidity rates have...
2.
Donovan-Banfield I, Turnell A, Hiscox J, Leppard K, Matthews D
Commun Biol
. 2020 Mar;
3(1):124.
PMID: 32170151
Viral genomes have high gene densities and complex transcription strategies rendering transcriptome analysis through short-read RNA-seq approaches problematic. Adenovirus transcription and splicing is especially complex. We used long-read direct RNA...
3.
Atwan Z, Wright J, Woodman A, Leppard K
J Gen Virol
. 2016 May;
97(8):1955-1967.
PMID: 27217299
Promyelocytic leukemia (PML) proteins have been implicated in antiviral responses but PML and associated proteins are also suggested to support virus replication. One isoform, PML-II, is required for efficient transcription...
4.
Windheim M, Honing S, Leppard K, Butler L, Seed C, Ponnambalam S, et al.
J Biol Chem
. 2016 Feb;
291(13):6796-812.
PMID: 26841862
The E3 transcription unit of human species C adenoviruses (Ads) encodes immunomodulatory proteins that mediate direct protection of infected cells. Recently, we described a novel immunomodulatory function for E3/49K, an...
5.
Bridges R, Sohn S, Wright J, Leppard K, Hearing P
mBio
. 2016 Jan;
7(1):e02184-15.
PMID: 26814176
Unlabelled: Modulation of host cell transcription, translation, and posttranslational modification processes is critical for the ability of many viruses to replicate efficiently within host cells. The human adenovirus (Ad) early...
6.
Maunder H, Taylor G, Leppard K, Easton A
Vaccine
. 2015 Nov;
33(48):6641-9.
PMID: 26529077
Pneumonia virus of mice (PVM) infection of BALB/c mice induces bronchiolitis leading to a fatal pneumonia in a dose-dependent manner, closely paralleling the development of severe disease during human respiratory...
7.
Wright J, Atwan Z, Morris S, Leppard K
J Virol
. 2015 May;
89(14):7053-63.
PMID: 25926634
Unlabelled: The late phase of adenovirus gene expression is controlled by proteins made in the intermediate phase, including L4 proteins of 22,000- and 33,000-Da apparent molecular mass (L4-22K and -33K...
8.
Chen Y, Wright J, Meng X, Leppard K
Mol Cell Biol
. 2015 Mar;
35(10):1660-72.
PMID: 25733689
To trigger type I interferon (IFN) responses, pattern recognition receptors activate signaling cascades that lead to transcription of IFN and IFN-stimulated genes (ISGs). The promyelocytic leukemia (PML) protein has been...
9.
Wright J, Leppard K
J Virol
. 2013 Aug;
87(21):11617-25.
PMID: 23966406
During adenovirus infection, the emphasis of gene expression switches from early genes to late genes in a highly regulated manner. Two gene products, L4-22K and L4-33K, contribute to this switch...
10.
Morris S, Farley D, Leppard K
BMC Biotechnol
. 2010 Dec;
10:92.
PMID: 21182761
Background: Adenovirus serotype 5 (Ad5) has many favourable characteristics for development as a gene therapy vector. However, the utility of current Ad5 vectors is limited by transient transgene expression, toxicity...