Keith M Derbyshire
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Explore the profile of Keith M Derbyshire including associated specialties, affiliations and a list of published articles.
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39
Citations
1049
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Recent Articles
1.
Derbyshire K, Salfinger M
J Clin Microbiol
. 2023 Sep;
61(10):e0062823.
PMID: 37724858
Macrolides, such as clarithromycin, are crucial in the treatment of nontuberculous mycobacteria (NTM). NTM are notoriously innately drug resistant, which has made the dependence on macrolides for their treatment even...
2.
Klever A, Alexander K, Almeida D, Anderson M, Ball R, Beamer G, et al.
Tuberculosis (Edinb)
. 2023 Aug;
142:102377.
PMID: 37531864
The Many Hosts of Mycobacteria (MHM) meeting series brings together basic scientists, clinicians and veterinarians to promote robust discussion and dissemination of recent advances in our knowledge of numerous mycobacterial...
3.
Majumdar S, Deep A, Sharma M, Canestrari J, Stone M, Smith C, et al.
bioRxiv
. 2023 Apr;
PMID: 37034768
Treatment of tuberculosis continues to be challenging due to the widespread latent form of the disease and the emergence of antibiotic-resistant strains of the pathogen, . Bacterial ribosomes are a...
4.
Sparks I, Derbyshire K, Jacobs Jr W, Morita Y
J Bacteriol
. 2023 Jan;
205(1):e0033722.
PMID: 36598232
The genus Mycobacterium contains several slow-growing human pathogens, including Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium. Mycobacterium smegmatis is a nonpathogenic and fast growing species within this genus. In 1990,...
5.
Smith C, Canestrari J, Wang A, Champion M, Derbyshire K, Gray T, et al.
Elife
. 2022 Mar;
11.
PMID: 35343439
Most bacterial ORFs are identified by automated prediction algorithms. However, these algorithms often fail to identify ORFs lacking canonical features such as a length of >50 codons or the presence...
6.
Zhu J, Wolf I, Dulberger C, Won H, Kester J, Judd J, et al.
Cell Rep
. 2021 Dec;
37(13):110154.
PMID: 34965429
Although prokaryotic organisms lack traditional organelles, they must still organize cellular structures in space and time, challenges that different species solve differently. To systematically define the subcellular architecture of mycobacteria,...
7.
Rokicki C, Brenner J, Dills A, Judd J, Kester J, Puffal J, et al.
J Bacteriol
. 2021 Sep;
203(22):e0041921.
PMID: 34516286
Mycobacteria spatially organize their plasma membrane, and many enzymes involved in envelope biosynthesis associate with a membrane compartment termed the intracellular membrane domain (IMD). The IMD is concentrated in the...
8.
Canestrari J, Lasek-Nesselquist E, Upadhyay A, Rofaeil M, Champion M, Wade J, et al.
Mol Microbiol
. 2020 Mar;
114(1):93-108.
PMID: 32181921
Genome-wide transcriptomic analyses have revealed abundant expressed short open reading frames (ORFs) in bacteria. Whether these short ORFs, or the small proteins they encode, are functional remains an open question....
9.
Clark R, Gray T, Derbyshire K
Methods Mol Biol
. 2019 Oct;
2075:123-134.
PMID: 31584159
Horizontal gene transfer (HGT) in prokaryotes disseminates genetic information throughout a population and can facilitate adaptation and evolution of the species. Mycobacteria utilize an atypical method of conjugation called distributive...
10.
Li Y, Sharma M, Koripella R, Wade J, Gray T, Derbyshire K, et al.
Proc Natl Acad Sci U S A
. 2019 Jan;
116(7):2398-2399.
PMID: 30683729
No abstract available.