Keith M Derbyshire
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Explore the profile of Keith M Derbyshire including associated specialties, affiliations and a list of published articles.
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39
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1049
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Recent Articles
11.
Li Y, Sharma M, Koripella R, Yang Y, Kaushal P, Lin Q, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(32):8191-8196.
PMID: 30038002
Bacteria respond to zinc starvation by replacing ribosomal proteins that have the zinc-binding CXXC motif (C+) with their zinc-free (C-) paralogues. Consequences of this process beyond zinc homeostasis are unknown....
12.
Clark R, Judd J, Lasek-Nesselquist E, Montgomery S, Hoffmann J, Derbyshire K, et al.
Proc Natl Acad Sci U S A
. 2018 Jun;
115(28):E6595-E6603.
PMID: 29941598
Conjugal cell-cell contact between strains of induces the transcript, which encodes the putative primary substrates of the ESAT-6 secretion system 4 (ESX-4) secretion system. This recipient response was required for...
13.
Gray T, Derbyshire K
Mol Microbiol
. 2018 Apr;
108(6):601-613.
PMID: 29669186
This review discusses a novel form of horizontal gene transfer (HGT) found in mycobacteria called Distributive Conjugal Transfer (DCT). While satisfying the criteria for conjugation, DCT occurs by a mechanism...
14.
Judd J, Boucher N, Van Roey E, Gray T, Derbyshire K
J Bacteriol
. 2017 Aug;
199(20).
PMID: 28784812
Genetic redundancy can obscure phenotypic effects of single-gene mutations. Two individual mutations may be viable separately but are lethal when combined, thus synthetically linking the two gene products in an...
15.
Yang Y, Thomas J, Li Y, Vilcheze C, Derbyshire K, Jacobs Jr W, et al.
Mol Microbiol
. 2017 Jun;
105(5):794-809.
PMID: 28628249
Most mycobacterial species spontaneously form biofilms, inducing unique growth physiologies and reducing drug sensitivity. Biofilm growth progresses through three genetically programmed stages: substratum attachment, intercellular aggregation and architecture maturation. Growth...
16.
Gray T, Clark R, Boucher N, Lapierre P, Smith C, Derbyshire K
Science
. 2016 Nov;
354(6310):347-350.
PMID: 27846571
Communal bacterial processes require intercellular communication mediated by secretion systems to coordinate appropriate molecular responses. Intercellular communication has not been described previously in mycobacteria. Here we show that the ESX...
17.
Shell S, Wang J, Lapierre P, Mir M, Chase M, Pyle M, et al.
PLoS Genet
. 2015 Nov;
11(11):e1005641.
PMID: 26536359
RNA-seq technologies have provided significant insight into the transcription networks of mycobacteria. However, such studies provide no definitive information on the translational landscape. Here, we use a combination of high-throughput...
18.
Derbyshire K, Gray T
Microbiol Spectr
. 2015 Jun;
2(1):MGM2-0022-2013.
PMID: 26082110
The past decade has seen an explosion in the application of genomic tools across all biological disciplines. This is also true for mycobacteria, where whole-genome sequences are now available for...
19.
Derbyshire K, Gray T
Microbiol Spectr
. 2014 Dec;
2(1).
PMID: 25505644
The last decade has seen an explosion in the application of genomic tools across all biological disciplines. This is also true for mycobacteria, where whole genome sequences are now available...
20.
Gray T, Krywy J, Harold J, Palumbo M, Derbyshire K
PLoS Biol
. 2013 Jul;
11(7):e1001602.
PMID: 23874149
Horizontal gene transfer (HGT) in bacteria generates variation and drives evolution, and conjugation is considered a major contributor as it can mediate transfer of large segments of DNA between strains...