Keith Leung
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Explore the profile of Keith Leung including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
251
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Recent Articles
1.
Kong M, Fang C, Yung C, Kwok T, Leung K, Leung F
Arch Osteoporos
. 2025 Jan;
20(1):10.
PMID: 39821704
Purpose: To evaluate grip strength and hand muscle cross-sectional area as predictors of secondary fracture risk in patients with a history of distal radius fracture (DRF), serving as surrogates of...
2.
Chen Z, Zeng C, Yang L, Che Y, Chen M, Sau L, et al.
Cell
. 2024 Dec;
188(2):331-351.e30.
PMID: 39694037
Long-term durable remission in patients with B cell malignancies following chimeric antigen receptor (CAR)-T cell immunotherapy remains unsatisfactory, often due to antigen escape. Malignant B cell transformation and oncogenic growth...
3.
Chen M, Shen C, Chen Y, Chen Z, Zhou K, Chen Y, et al.
Cell Rep Med
. 2024 Jul;
5(7):101645.
PMID: 39019012
Fms-like tyrosine kinase 3 (FLT3) mutations, present in over 30% of acute myeloid leukemia (AML) cases and dominated by FLT3-internal tandem duplication (FLT3-ITD), are associated with poor outcomes in patients...
4.
Xue M, Dong L, Zhang H, Li Y, Qiu K, Zhao Z, et al.
J Hematol Oncol
. 2024 Feb;
17(1):7.
PMID: 38302992
Background: While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains elusive. We...
5.
Zhang Z, Zhou K, Han L, Small A, Xue J, Huang H, et al.
Genes Dis
. 2023 Aug;
11(1):382-396.
PMID: 37588203
As the most common internal modification of mRNA-methyladenosine (mA) and its regulators modulate gene expression and play critical roles in various biological and pathological processes including tumorigenesis. It was reported...
6.
Li Y, Xue M, Deng X, Dong L, Truong Nguyen L, Ren L, et al.
Cell Stem Cell
. 2023 Aug;
30(8):1072-1090.e10.
PMID: 37541212
TET2 is recurrently mutated in acute myeloid leukemia (AML) and its deficiency promotes leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem cell (LSC) self-renewal. However, the underlying cellular/molecular...
7.
Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, et al.
Cell
. 2023 Jun;
186(15):3208-3226.e27.
PMID: 37379838
N-methylguanosine (mG) modification, routinely occurring at mRNA 5' cap or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although mG-cap is essential for pre-mRNA processing and protein synthesis, the...
8.
Chen Z, Zhou K, Xue J, Small A, Xiao G, Truong Nguyen L, et al.
Sci Transl Med
. 2023 Mar;
15(689):eabq8513.
PMID: 36989375
Although the overall survival rate of B cell acute lymphoblastic leukemia (B-ALL) in childhood is more than 80%, it is merely 30% in refractory/relapsed and adult patients with B-ALL. This...
9.
Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, et al.
Cell Stem Cell
. 2023 Jan;
30(1):52-68.e13.
PMID: 36608679
N-methyladenosine (mA), the most prevalent internal modification in mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently identified mA methyltransferase. However, its role in leukemia has yet...
10.
Tan B, Zhou K, Liu W, Prince E, Qing Y, Li Y, et al.
Theranostics
. 2022 Aug;
12(13):5727-5743.
PMID: 35966596
Methods: and models were employed to determine the pathological function of in TNBC metastasis. To identify YTHDC1 target RNAs, we conducted RNA-seq, mA-seq, and RIP-seq, followed by integrative data analysis...