Keith James
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Explore the profile of Keith James including associated specialties, affiliations and a list of published articles.
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23
Citations
2963
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Recent Articles
1.
Wang M, Burlacu G, Truxillo D, James K, Yao X
J Appl Psychol
. 2014 Dec;
100(4):1296-308.
PMID: 25546265
Organizations worldwide are currently experiencing shifts in the age composition of their workforces. The workforce is aging and becoming increasingly age-diverse, suggesting that organizational researchers and practitioners need to better...
2.
Chouhan G, James K
Org Lett
. 2013 Mar;
15(6):1206-9.
PMID: 23464978
A range of macrocyclic β-turn mimetic tetrapeptides was prepared by efficient copper-tris(triazole) ligand complex catalyzed azide-alkyne "click" macrocyclizations in good to high yields. Preliminary conformational studies using X-ray crystallography and...
3.
Perkins T, Davies M, Klemm E, Rowley G, Wileman T, James K, et al.
Mol Microbiol
. 2012 Nov;
87(3):526-38.
PMID: 23190111
OmpR is a multifunctional DNA binding regulator with orthologues in many enteric bacteria that exhibits classical regulator activity as well as nucleoid-associated protein-like characteristics. In the enteric pathogen Salmonella enterica,...
4.
Collins J, Farley K, Limberakis C, Liras S, Price D, James K
J Org Chem
. 2012 Nov;
77(24):11079-90.
PMID: 23167628
Conditions have been identified for the efficient Ullmann macrocyclization of phenol and imidazole nucleophiles with aryl iodides at high reaction concentrations of up to 100 mM and using 5-10 mol...
5.
Dong H, Limberakis C, Liras S, Price D, James K
Chem Commun (Camb)
. 2012 Oct;
48(95):11644-6.
PMID: 23096995
A highly efficient macrocyclization reaction has been developed via the palladium-catalyzed C-H arylation of the side-chains of tryptophan with halophenyl-containing amino acids. This method allows for direct access to 15-...
6.
Lange P, James K
ACS Comb Sci
. 2012 Sep;
14(10):570-8.
PMID: 22954105
A novel methodology for the synthesis of druglike heterocycle libraries has been developed through the use of flow reactor technology. The strategy employs orthogonal modification of a heterocyclic core, which...
7.
Meyer F, Collins J, Borin B, Bradow J, Liras S, Limberakis C, et al.
J Org Chem
. 2012 Feb;
77(7):3099-114.
PMID: 22352804
A general method for constraining peptide conformations via linkage of aromatic sidechains has been developed. Macrocyclization of suitably functionalized tri-, tetra- and pentapeptides via Suzuki-Miyaura cross-coupling has been used to...
8.
Bogdan A, Jerome S, Houk K, James K
J Am Chem Soc
. 2011 Dec;
134(4):2127-38.
PMID: 22133103
The synthesis, X-ray crystal structures, and calculated strain energies are reported for a homologous series of 11- to 14-membered drug-like cyclophane macrocycles, representing an unusual region of chemical space that...
9.
Bogdan A, Davies N, James K
Org Biomol Chem
. 2011 Oct;
9(22):7727-33.
PMID: 21979439
The diffusion coefficients of a series of closely matched pairs of macrocyclic and linear molecules have been compared using NMR spectroscopy. The macrocyclic series was designed both to overlap with...
10.
Bogdan A, James K
Org Lett
. 2011 Jul;
13(15):4060-3.
PMID: 21739952
A new macrocyclization strategy to synthesize 12- to 31-membered 5-iodo-1,2,3-triazole-containing macrocycles is described. The macrocycles have been generated using a simple and efficient copper-catalyzed cycloaddition in flow under environmentally friendly...