Keith Clinch
Overview
Explore the profile of Keith Clinch including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
32
Citations
435
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0
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Recent Articles
1.
Glockzin K, Meneely K, Hughes R, Maatouk S, Pina G, Suthagar K, et al.
Biochemistry
. 2023 Jul;
62(14):2182-2201.
PMID: 37418678
Over 70 million people are currently at risk of developing Chagas Disease (CD) infection, with more than 8 million people already infected worldwide. Current treatments are limited and innovative therapies...
2.
Sparrow K, Shrestha R, Wood J, Clinch K, Hurst B, Wang H, et al.
ACS Med Chem Lett
. 2023 Apr;
14(4):506-513.
PMID: 37077387
We report for the first time the antiviral activities of two (antiviral imino--nucleosides) and , structurally related to galidesivir (Immucillin A, BCX4430). An containing the 4-aminopyrrolo[2,1-][1,2,4-triazine] nucleobase found in remdesivir...
3.
Minnow Y, Suthagar K, Clinch K, Ducati R, Ghosh A, Buckler J, et al.
ACS Chem Biol
. 2022 Nov;
17(12):3407-3419.
PMID: 36413975
hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is essential for purine salvage of hypoxanthine into parasite purine nucleotides. Transition state analogue inhibitors of HGXPRT are characterized by kinetic analysis, thermodynamic parameters, and X-ray crystal...
4.
Glockzin K, Kostomiris D, Minnow Y, Suthagar K, Clinch K, Gai S, et al.
Biochemistry
. 2022 Oct;
61(19):2088-2105.
PMID: 36193631
Chagas disease, caused by the parasitic protozoan , affects over 8 million people worldwide. Current antiparasitic treatments for Chagas disease are ineffective in treating advanced, chronic stages of the disease,...
5.
Popadynec M, Baradaran-Heravi A, Alford B, Cameron S, Clinch K, Mason J, et al.
ACS Med Chem Lett
. 2021 Sep;
12(9):1486-1492.
PMID: 34531957
A significant proportion of genetic disease cases arise from truncation of proteins caused by premature termination codons. In eukaryotic cells some aminoglycosides cause readthrough of premature termination codons during protein...
6.
Mutreja I, Warring S, Lim K, Swadi T, Clinch K, Mason J, et al.
ACS Biomater Sci Eng
. 2021 Jan;
5(2):748-758.
PMID: 33405836
The rise of antibiotic resistance, coupled with increased expectations for mobility in later life, is creating a need for biofilm inhibitors and delivery systems that will reduce surgical implant infection....
7.
Freitas E, Nico D, Alves-Silva M, Morrot A, Clinch K, Evans G, et al.
PLoS Negl Trop Dis
. 2015 Dec;
9(12):e0004297.
PMID: 26701750
Background: Immucillins ImmA (IA), ImmH (IH) and SerMe-ImmH (SMIH) are synthetic deazapurine nucleoside analogues that inhibit Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis multiplication in vitro without macrophage toxicity....
8.
Wang S, Cameron S, Clinch K, Evans G, Wu Z, Schramm V, et al.
J Am Chem Soc
. 2015 Oct;
137(45):14275-80.
PMID: 26494017
Helicobacter pylori is a Gram-negative bacterium that colonizes the gut of over 50% of the world's population. It is responsible for most peptic ulcers and is an important risk factor...
9.
Freitas E, Nico D, Guan R, Meyer-Fernandes J, Clinch K, Evans G, et al.
PLoS One
. 2015 Apr;
10(4):e0124183.
PMID: 25909893
Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources. Nucleoside hydrolases release purines from nucleosides...
10.
Zhang Y, Evans G, Clinch K, Crump D, Harris L, Frohlich R, et al.
J Biol Chem
. 2013 Oct;
288(48):34746-54.
PMID: 24158442
The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component...