Keisuke Shirai
Overview
Explore the profile of Keisuke Shirai including associated specialties, affiliations and a list of published articles.
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78
Citations
2306
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Recent Articles
1.
Zhang Z, Sehgal K, Shirai K, Butler R, Wiencke J, Koestler D, et al.
NPJ Precis Oncol
. 2024 Nov;
8(1):267.
PMID: 39558036
Tissue biomarkers for immune checkpoint inhibitor (ICI) response are limited by tumor sample heterogeneity and availability. This study identifies clinically actionable pretreatment blood biomarkers that are associated with ICI treatment...
2.
Ramirez D, Dragnev C, Searles T, Spicer N, Chen T, Lines J, et al.
J Immunother Cancer
. 2024 Nov;
12(11).
PMID: 39521617
Background: Overcoming immune suppression is a major barrier to eliciting potent CD8 T cell responses against cancer. Treatment with anti-CD4 monoclonal antibody is an effective means for eliminating CD4Foxp3 regulatory...
3.
McGillivray E, Ashouri K, Chatziioannou E, Ocejo Gallegos J, Zarka J, Kechter J, et al.
Br J Dermatol
. 2024 Oct;
192(2):316-326.
PMID: 39438074
Background: Combination immune checkpoint blockade targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) leads to high response rates and improved survival in patients with...
4.
Ashina M, Kido T, Shirai K, Masuda Y, Imagawa Y, Nakata Y, et al.
Pediatr Res
. 2024 Aug;
PMID: 39169223
Background: Meconium peritonitis is a noninfectious chemical peritonitis that occurs following fetal intestinal perforation and leakage of meconium into the abdominal cavity. Because of the lack of appropriate animal models,...
5.
Isaacs J, Degefu H, Chen T, Kleist S, Musial S, Ford M, et al.
J Immunol
. 2024 Jul;
213(5):588-599.
PMID: 38975728
The ecto-ATPase CD39 is expressed on exhausted CD8+ T cells in chronic viral infection and has been proposed as a marker of tumor-specific CD8+ T cells in cancer, but the...
6.
Matsuda K, Nagano N, Nakazaki K, Katayama D, Tokunaga W, Okuda K, et al.
Nutrients
. 2024 Jun;
16(11).
PMID: 38892554
This study examined whey protein's impact on insulin resistance in a high-fat diet-induced pediatric obesity mouse model. Pregnant mice were fed high-fat diets, and male pups continued this diet until...
7.
Lee M, Zhang Z, Sehgal K, Butler R, Stolrow H, Ramush G, et al.
Epigenomics
. 2024 Jun;
16(11-12):799-807.
PMID: 38869472
This study addresses the challenge of predicting the response of head and neck squamous cell carcinoma (HNSCC) patients to immunotherapy. Using DNA methylation cytometry, we analyzed the immune profiles of...
8.
Fay K, Finley D, Hasson R, Millington T, Emond J, Shirai K, et al.
J Surg Res
. 2024 Jun;
300:345-351.
PMID: 38843721
Introduction: Food desert (FD) residence has emerged as a risk factor for poor outcomes in breast, colon and esophageal cancers. The purpose of this retrospective study was to examine FD...
9.
Isaacs J, Degefu H, Chen T, Kleist S, Musial S, Ford M, et al.
bioRxiv
. 2024 Apr;
PMID: 38559200
The ecto-ATPase CD39 is expressed on exhausted CD8+ T cells in chronic viral infection and has been proposed as a marker of tumor-specific CD8+ T cells in cancer, but the...
10.
Palmer J, Suriawinata A, Yan S, Kerr D, Afzal M, Shirai K
Am J Case Rep
. 2023 Nov;
24:e938537.
PMID: 37978795
BACKGROUND Early therapies for metastatic melanoma improved patient quality of life; however, median survival remained unaffected. Studies are showing that surgical excision with the combination of immune checkpoint inhibitor (ICI)...