Tyler G Searles
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Explore the profile of Tyler G Searles including associated specialties, affiliations and a list of published articles.
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8
Citations
212
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Recent Articles
1.
Ramirez D, Dragnev C, Searles T, Spicer N, Chen T, Lines J, et al.
J Immunother Cancer
. 2024 Nov;
12(11).
PMID: 39521617
Background: Overcoming immune suppression is a major barrier to eliciting potent CD8 T cell responses against cancer. Treatment with anti-CD4 monoclonal antibody is an effective means for eliminating CD4Foxp3 regulatory...
2.
Isaacs J, Degefu H, Chen T, Kleist S, Musial S, Ford M, et al.
J Immunol
. 2024 Jul;
213(5):588-599.
PMID: 38975728
The ecto-ATPase CD39 is expressed on exhausted CD8+ T cells in chronic viral infection and has been proposed as a marker of tumor-specific CD8+ T cells in cancer, but the...
3.
Isaacs J, Degefu H, Chen T, Kleist S, Musial S, Ford M, et al.
bioRxiv
. 2024 Apr;
PMID: 38559200
The ecto-ATPase CD39 is expressed on exhausted CD8+ T cells in chronic viral infection and has been proposed as a marker of tumor-specific CD8+ T cells in cancer, but the...
4.
Phillips J, Fay K, Bergeron A, Zhang P, Mielcarz D, Calkins A, et al.
Curr Oncol
. 2023 May;
30(5):5116-5134.
PMID: 37232845
This pilot study sought to evaluate the circulating levels of immune cells, particularly regulatory T-cell (Treg) subsets, before and after lung resection for non-small cell lung cancer. Twenty-five patients consented...
5.
Fitzpatrick K, Degefu H, Poljakov K, Bibby M, Remington A, Searles T, et al.
J Immunol
. 2023 Mar;
210(8):1156-1165.
PMID: 36883850
The study of Ag-specific lymphocytes has been a key advancement in immunology over the past few decades. The development of multimerized probes containing Ags, peptide:MHC complexes, or other ligands was...
6.
Molodtsov A, Khatwani N, Vella J, Lewis K, Zhao Y, Han J, et al.
Immunity
. 2021 Sep;
54(9):2117-2132.e7.
PMID: 34525340
The nature of the anti-tumor immune response changes as primary tumors progress and metastasize. We investigated the role of resident memory (Trm) and circulating memory (Tcirm) cells in anti-tumor responses...
7.
Han J, Zhao Y, Shirai K, Molodtsov A, Kolling F, Fisher J, et al.
Nat Cancer
. 2021 Jun;
2(3):300-311.
PMID: 34179824
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived memory has been poorly characterized. In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, we probed...
8.
Han J, Khatwani N, Searles T, Turk M, Angeles C
Semin Immunol
. 2020 Dec;
49:101435.
PMID: 33272898
Long-lived memory CD8 T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8 T cells - central, effector, stem-like,...