Keiko Osawa
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Explore the profile of Keiko Osawa including associated specialties, affiliations and a list of published articles.
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17
Citations
899
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Recent Articles
1.
Cale E, Shen C, Olia A, Radakovich N, Rawi R, Yang Y, et al.
Cell Rep
. 2024 Dec;
43(12):115010.
PMID: 39675002
Antibodies that target the gp120-gp41 interface of the HIV-1 envelope (Env) trimer comprise a commonly elicited category of broadly neutralizing antibodies (bNAbs). Here, we isolate and characterize VRC44, a bNAb...
2.
DAddabbo A, Tong T, Crooks E, Osawa K, Xu J, Thomas A, et al.
Glycobiology
. 2024 Aug;
34(11).
PMID: 39115361
Broadly neutralizing antibodies (bNAbs) isolated from HIV-1 infected donors are vaccine paradigms. These bNAbs recognize envelope glycoprotein trimers that carry 75-90 oligomannose and complex-type glycans. Although bNAbs and their precursors...
3.
Crooks E, Almanza F, DAddabbo A, Duggan E, Zhang J, Wagh K, et al.
PLoS Pathog
. 2021 Oct;
17(10):e1009807.
PMID: 34679128
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets-the V2...
4.
Crooks E, Grimley S, Cully M, Osawa K, Dekkers G, Saunders K, et al.
PLoS Pathog
. 2018 May;
14(5):e1007024.
PMID: 29718999
The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and...
5.
Cale E, Gorman J, Radakovich N, Crooks E, Osawa K, Tong T, et al.
Immunity
. 2017 May;
46(5):777-791.e10.
PMID: 28514685
Most HIV-1-specific neutralizing antibodies isolated to date exhibit unusual characteristics that complicate their elicitation. Neutralizing antibodies that target the V1V2 apex of the HIV-1 envelope (Env) trimer feature unusually long...
6.
Crooks E, Osawa K, Tong T, Grimley S, Dai Y, Whalen R, et al.
Virology
. 2017 Mar;
505:193-209.
PMID: 28279830
Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position...
7.
Kwon Y, Pancera M, Acharya P, Georgiev I, Crooks E, Gorman J, et al.
Nat Struct Mol Biol
. 2015 Jun;
22(7):522-31.
PMID: 26098315
As the sole viral antigen on the HIV-1-virion surface, trimeric Env is a focus of vaccine efforts. Here we present the structure of the ligand-free HIV-1-Env trimer, fix its conformation...
8.
Crooks E, Tong T, Chakrabarti B, Narayan K, Georgiev I, Menis S, et al.
PLoS Pathog
. 2015 May;
11(5):e1004932.
PMID: 26023780
Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually...
9.
Tong T, Crooks E, Osawa K, Robinson J, Barnes M, Apetrei C, et al.
Virology
. 2014 Jun;
456-457:55-69.
PMID: 24889225
Virus-like particles (VLPs) offer a platform to test the hypothesis that, since antibody binding to native envelope glycoprotein (Env) trimers results in HIV-1 neutralization, that native Env trimers presented in...
10.
Tong T, Crooks E, Osawa K, Robinson J, Barnes M, Apetrei C, et al.
Virology
. 2014 Jun;
456-457:55-69.
PMID: 24882891
Virus-like particles (VLPs) offer a platform to test the hypothesis that, since antibody binding to native envelope glycoprotein (Env) trimers results in HIV-1 neutralization, that native Env trimers presented in...