Ema T Crooks
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Explore the profile of Ema T Crooks including associated specialties, affiliations and a list of published articles.
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12
Citations
914
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Recent Articles
1.
McCaul N, Quandte M, Bontjer I, van Zadelhoff G, Land A, Crooks E, et al.
Cell Rep
. 2021 Sep;
36(9):109646.
PMID: 34469718
Removal of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding. While generally thought to be removed co-translationally, we report two...
2.
Crooks E, Grimley S, Cully M, Osawa K, Dekkers G, Saunders K, et al.
PLoS Pathog
. 2018 May;
14(5):e1007024.
PMID: 29718999
The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and...
3.
Cale E, Gorman J, Radakovich N, Crooks E, Osawa K, Tong T, et al.
Immunity
. 2017 May;
46(5):777-791.e10.
PMID: 28514685
Most HIV-1-specific neutralizing antibodies isolated to date exhibit unusual characteristics that complicate their elicitation. Neutralizing antibodies that target the V1V2 apex of the HIV-1 envelope (Env) trimer feature unusually long...
4.
Crooks E, Osawa K, Tong T, Grimley S, Dai Y, Whalen R, et al.
Virology
. 2017 Mar;
505:193-209.
PMID: 28279830
Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position...
5.
Crooks E, Tong T, Chakrabarti B, Narayan K, Georgiev I, Menis S, et al.
PLoS Pathog
. 2015 May;
11(5):e1004932.
PMID: 26023780
Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually...
6.
Tong T, Crooks E, Osawa K, Robinson J, Barnes M, Apetrei C, et al.
Virology
. 2014 Jun;
456-457:55-69.
PMID: 24889225
Virus-like particles (VLPs) offer a platform to test the hypothesis that, since antibody binding to native envelope glycoprotein (Env) trimers results in HIV-1 neutralization, that native Env trimers presented in...
7.
Tong T, Crooks E, Osawa K, Robinson J, Barnes M, Apetrei C, et al.
Virology
. 2014 Jun;
456-457:55-69.
PMID: 24882891
Virus-like particles (VLPs) offer a platform to test the hypothesis that, since antibody binding to native envelope glycoprotein (Env) trimers results in HIV-1 neutralization, that native Env trimers presented in...
8.
Doria-Rose N, Schramm C, Gorman J, Moore P, Bhiman J, DeKosky B, et al.
Nature
. 2014 Mar;
509(7498):55-62.
PMID: 24590074
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the...
9.
Tong T, Osawa K, Robinson J, Crooks E, Binley J
J Virol
. 2013 Jun;
87(16):9233-49.
PMID: 23740975
In natural infection, antibodies interact with HIV-1 primarily through nonfunctional forms of envelope glycoproteins (Env), including uncleaved (UNC) gp160 and gp41 stumps. These antigens are important to fully characterize, as...
10.
Selhorst P, Grupping K, Tong T, Crooks E, Martin L, Vanham G, et al.
Retrovirology
. 2013 Feb;
10:12.
PMID: 23375046
Background: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen....