Keiko Koga
Overview
Explore the profile of Keiko Koga including associated specialties, affiliations and a list of published articles.
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24
Citations
769
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Recent Articles
1.
Yano H, Koga K, Sato T, Shinohara T, Iriguchi S, Matsuda A, et al.
Cell Stem Cell
. 2024 Jun;
31(6):795-802.e6.
PMID: 38848686
CD4 T cells induced from human iPSCs (iCD4 T cells) offer a therapeutic opportunity for overcoming immune pathologies arising from hematopoietic stem cell transplantation. However, most iCD4 T cells are...
2.
Kojima M, Suzuki K, Takeshita M, Ohyagi M, Iizuka M, Yamane H, et al.
Commun Biol
. 2023 May;
6(1):500.
PMID: 37161050
T cells play important roles in autoimmune diseases, but it remains unclear how to optimally manipulate them. We focused on the T cell immunoreceptor with Ig and ITIM domains (TIGIT),...
3.
Inamo J, Suzuki K, Takeshita M, Kondo Y, Okuzono Y, Koga K, et al.
Sci Rep
. 2021 Aug;
11(1):16691.
PMID: 34404865
While numerous disease-modifying anti-rheumatic drugs (DMARDs) have brought about a dramatic paradigm shift in the management of rheumatoid arthritis (RA), unmet needs remain, such as the small proportion of patients...
4.
Murata O, Suzuki K, Sugiura H, Kondo Y, Takeshita M, Koga K, et al.
Rheumatology (Oxford)
. 2021 Feb;
60(12):5595-5600.
PMID: 33590850
Objectives: We sought to clarify the presence of radiographic thymus variants using a scoring system, and their association with clinical and immunological features in RA patients. Methods: A total of...
5.
Koga K, Wang B, Kaneko S
Inflamm Regen
. 2020 Oct;
40:23.
PMID: 33014207
In 2007, Human-induced pluripotent stem cells (iPSCs) were generated by transducing four genes (Oct3/4, Sox2, Klf4, c-Myc). Because iPSCs can differentiate into any types of cells in the body and...
6.
Takeshita M, Suzuki K, Kondo Y, Morita R, Okuzono Y, Koga K, et al.
Ann Rheum Dis
. 2019 Jun;
78(10):1346-1356.
PMID: 31167762
Objectives: Rheumatoid arthritis (RA) is an autoimmune disease accompanied by lymphocyte infiltration into joint synovium. While T cells are considered to be important for its pathogenesis, the features that are...
7.
Fukase Y, Sato A, Tomata Y, Ochida A, Kono M, Yonemori K, et al.
Bioorg Med Chem
. 2018 Jan;
26(3):721-736.
PMID: 29342416
Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of inflammatory and autoimmune diseases. A hit compound, 1, was...
8.
Shirai J, Tomata Y, Kono M, Ochida A, Fukase Y, Sato A, et al.
Bioorg Med Chem
. 2017 Dec;
26(2):483-500.
PMID: 29262987
A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered through optimization of a high-throughput screen hit 1. (R)-N-(2-((3,5-Difluoro-4-(trimethylsilyl)phenyl) amino)-1-(4-methoxyphenyl)-2-oxoethyl)-3-hydroxy-N-methylisoxazole-5-carboxamide (22) was identified...
9.
Kondo T, Morita R, Okuzono Y, Nakatsukasa H, Sekiya T, Chikuma S, et al.
Nat Commun
. 2017 May;
8:15338.
PMID: 28530241
Adoptive T-cell immunotherapy is a promising approach to cancer therapy. Stem cell memory T (T) cells have been proposed as a class of long-lived and highly proliferative memory T cells....
10.
Akiyama M, Yasuoka H, Yamaoka K, Suzuki K, Kaneko Y, Kondo H, et al.
Arthritis Res Ther
. 2016 Jul;
18:167.
PMID: 27411315
Background: The aim of this study was to elucidate the function of circulating follicular helper T (Tfh) cell subsets in helping B cells in patients with active, untreated IgG4-related disease...