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Keigo Machida

Explore the profile of Keigo Machida including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 87
Citations 3105
Followers 0
Related Specialties
Gastroenterology
Biology
General Medicine
Top 10 Co-Authors
Hidekazu Tsukamoto
Michael M C Lai
Stanley M Tahara
Chia-Lin Chen
Juan Carlos Hernandez
Linda Sher
Jing-Hsiung James Ou
Vasu Punj
Hye Yeon Choi
Tatsuya Machida
Published In
J Virol
Nat Commun
iScience
J Biol Chem
Hepatology
Affiliations
Soon will be listed here.
Recent Articles
1.
Retraction Notice to: LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells
Hernandez J, Chen C, Machida T, Uthaya Kumar D, Tahara S, Montana J, et al.
iScience . 2025 Mar; 28(3):112032. PMID: 40060897
[This retracts the article DOI: 10.1016/j.isci.2023.106254.].
2.
Retraction Notice to: Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal
Yeh D, Liu C, Hernandez J, Tahara S, Tsukamoto H, Machida K
iScience . 2024 Dec; 27(12):111489. PMID: 39717084
[This retracts the article DOI: 10.1016/j.isci.2023.107035.].
3.
Author Correction: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells
Choi H, Zhu Y, Zhao X, Mehta S, Hernandez J, Lee J, et al.
Exp Mol Med . 2024 Oct; 56(10):2323. PMID: 39465353
No abstract available.
4.
Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
Chen C, Tsukamoto H, Liu J, Kashiwabara C, Feldman D, Sher L, et al.
J Clin Invest . 2024 Oct; 134(19). PMID: 39352392
No abstract available.
5.
NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells
Choi H, Zhu Y, Zhao X, Mehta S, Hernandez J, Lee J, et al.
Exp Mol Med . 2024 Feb; 56(2):461-477. PMID: 38409448
The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms governing the regulation of this pathway have not been fully elucidated. Here, we show that...
6.
Protocol for generation of humanized HCC mouse model and cancer-driver mutations using CRISPR-Cas9
Zhu Y, Tahara S, Tsukamoto H, Machida K
STAR Protoc . 2023 Dec; 4(4):102389. PMID: 38103196
We detail procedures for generating a humanized mouse model of hepatocellular carcinoma (HCC) recapitulating genetic mutations associated with metabolic liver diseases (MLD). We humanized liver parenchymal, non-parenchymal, and hematopoietic cells....
7.
β-CATENIN stabilizes HIF2 through lncRNA and inhibits intravenous immunoglobulin immunotherapy
Nakagawa C, Kadlera Nagaraj M, Hernandez J, Uthay Kumar D, Shukla V, Machida R, et al.
Front Immunol . 2023 Sep; 14:1204907. PMID: 37744383
Introduction: Tumor-initiating cells (TICs) are rare, stem-like, and highly malignant. Although intravenous hepatitis B and C immunoglobulins have been used for HBV and HCV neutralization in patients, their tumor-inhibitory effects...
8.
Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal
Yeh D, Liu C, Hernandez J, Tahara S, Tsukamoto H, Machida K
iScience . 2023 Jul; 26(7):107035. PMID: 37448562
The synergistic effect of alcohol and HCV mediated through TLR4 signaling transactivates NANOG, a pluripotency transcription factor important for the stemness of tumor-initiating stem-like cells (TICs). NANOG together with the...
9.
GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage
Ha D, Shin W, Hernandez J, Neamati N, Dubeau L, Machida K, et al.
Viruses . 2023 May; 15(5). PMID: 37243204
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, has given rise to many new variants with increased transmissibility and the ability to evade...
10.
Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis
Sinha S, Aizawa S, Nakano Y, Rialdi A, Choi H, Shrestha R, et al.
Nat Commun . 2023 May; 14(1):2651. PMID: 37156770
Hepatocellular carcinoma (HCC) is the 3 most deadly malignancy. Activated hepatic stellate cells (aHSC) give rise to cancer-associated fibroblasts in HCC and are considered a potential therapeutic target. Here we...