Kei-Ichi Sugiyama
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Explore the profile of Kei-Ichi Sugiyama including associated specialties, affiliations and a list of published articles.
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49
Citations
219
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Recent Articles
1.
Yamada H, Odagiri M, Yamakita K, Chiba A, Ukai A, Yasui M, et al.
Sci Rep
. 2025 Mar;
15(1):7780.
PMID: 40044744
Numerous chemicals are associated with carcinogenesis through epigenetic alterations in cells. To detect global epigenetic changes induced by carcinogens, the housekeeping gene can serve as a reporter locus, offering a...
2.
Furuhama A, Sugiyama K, Honma M
Regul Toxicol Pharmacol
. 2024 Dec;
156:105763.
PMID: 39662666
The Ames mutagenicity test is an effective means of screening compounds for their carcinogenic potential. Here, we conducted Ames tests on 15 aryl, benzyl, and aliphatic ring N-nitrosamines. Then, by...
3.
Muto S, Furuhama A, Yamamoto M, Otagiri Y, Koyama N, Hitaoka S, et al.
Genes Environ
. 2024 Nov;
46(1):24.
PMID: 39574188
Background: Primary aromatic amines (PAAs) present significant challenges in the prediction of mutagenicity using current standard quantitative structure activity relationship (QSAR) systems, which are knowledge-based and statistics-based, because of their...
4.
Hosoi S, Hirose T, Matsumura S, Otsubo Y, Saito K, Miyazawa M, et al.
Genes Environ
. 2024 Oct;
46(1):20.
PMID: 39385252
Background: Error-corrected next-generation sequencing (ecNGS) technologies have enabled the direct evaluation of genome-wide mutations after exposure to mutagens. Previously, we reported an ecNGS methodology, Hawk-Seq™, and demonstrated its utility in...
5.
Iso T, Suzuki K, Murata Y, Hirose N, Umano T, Horibata K, et al.
Genes Environ
. 2024 Feb;
46(1):7.
PMID: 38378650
Background: Carbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With respect to genotoxicity, carbendazim is deemed to be non-mutagenic in vitro, but...
6.
Mishima M, Sugiyama K
Genes Environ
. 2023 Dec;
45(1):36.
PMID: 38093344
Background: Middle size peptides (MSPs) have emerged as a promising new pharmaceutical modality. We are seeking the best way to assess the non-clinical safety of MSPs. Consideration: The requirements for...
7.
Izawa K, Tsuda M, Suzuki T, Honma M, Sugiyama K
Genes Environ
. 2023 Nov;
45(1):30.
PMID: 37993952
Background: Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment....
8.
Murata Y, Suzuki K, Shigeta Y, Iso T, Hirose N, Umano T, et al.
Genes Environ
. 2023 Nov;
45(1):29.
PMID: 37990244
Background: tert-Butyl hydroperoxide (TBHP; CAS 75-91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester. It is a high-production chemical, widely used...
9.
Shimizu N, Hamada Y, Morozumi R, Yamamoto J, Iwai S, Sugiyama K, et al.
J Biol Chem
. 2023 Jul;
299(8):104988.
PMID: 37392847
Topoisomerases are enzymes that relax DNA supercoiling during replication and transcription. Camptothecin, a topoisomerase 1 (TOP1) inhibitor, and its analogs trap TOP1 at the 3'-end of DNA as a DNA-bound...
10.
Murata Y, Natsume M, Iso T, Shigeta Y, Hirose N, Umano T, et al.
Genes Environ
. 2023 Apr;
45(1):12.
PMID: 37041654
Background: Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile-butadiene-styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers,...