Ke Ruan
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Explore the profile of Ke Ruan including associated specialties, affiliations and a list of published articles.
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Articles
52
Citations
529
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Recent Articles
1.
Zhong F, Pu T, Hu Q, Li M, Wang L, Wang S, et al.
Structure
. 2025 Jan;
33(3):443-450.e4.
PMID: 39862858
NSUN6 preferentially catalyzes the methylation of cytosine nucleotides in mRNA substrates, which enhances transcription. Dysregulation of NSUN6 catalysis drives the oncogenesis of certain cancers. In this study, we determined the...
2.
Zhong F, Zhou Y, Liu M, Wang L, Li F, Zhang J, et al.
ACS Chem Biol
. 2024 Nov;
19(12):2469-2476.
PMID: 39513479
The E3 ligase HOIP is vital for the NF-κB pathway and is implicated in cancer and immunity. However, it remains challenging to achieve high selectivity by directly targeting the conserved...
3.
Qin M, Fan W, Li L, Xu T, Zhang H, Chen F, et al.
Int J Biol Macromol
. 2024 Aug;
277(Pt 3):134411.
PMID: 39097054
Stress granules (SGs) are membrane-less organelles (MLOs) or cytosolic compartments formed upon exposure to environmental cell stress-inducing stimuli. SGs are based on ribonucleoprotein complexes from a set of cytoplasmic proteins...
4.
Qin M, Fan W, Chen F, Ruan K, Liu D
J Mol Biol
. 2024 Jul;
436(19):168727.
PMID: 39079611
Stress granules (SGs) are dynamic biomolecular condensates that form in the cytoplasm in response to cellular stress, encapsulating proteins and RNAs. Methylation is a key factor in the assembly of...
5.
Ruan K, Bai G, Fang Y, Li D, Li T, Liu X, et al.
Sci China Life Sci
. 2024 Jul;
67(9):1792-1832.
PMID: 39037698
Biomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid phase separation (LLPS) divide intracellular spaces into discrete compartments for specific functions. Dysregulation of LLPS or aberrant phase transition that disturbs...
6.
Wei X, Li S, Li Z, Wang L, Fan W, Ruan K, et al.
FEBS Lett
. 2024 Jul;
598(20):2533-2543.
PMID: 39031937
The PWWP domain of hepatoma-derived growth factor-related protein 2 (HDGFRP2) recognizes methylated histones to initiate the recruitment of homologous recombination repair proteins to damaged silent genes. The combined depletion of...
7.
Fan W, Xu T, Gao J, Zhang H, Li Y, Hu D, et al.
Chem Commun (Camb)
. 2023 Dec;
60(6):762-765.
PMID: 38126399
The formation of membrane-less organelles is driven by multivalent weak interactions while mediation of such interactions by small molecules remains an unparalleled challenge. Here, we uncovered a bivalent inhibitor that...
8.
Ruan K, Lin Y, Yang P, Zhou W
Nat Chem Biol
. 2023 Sep;
19(10):1180-1182.
PMID: 37731018
No abstract available.
9.
Xu D, Chen X, Kuang Y, Hong M, Xu T, Wang K, et al.
Cell Rep
. 2023 Aug;
42(8):112915.
PMID: 37537842
The nucleolus is the most prominent membraneless organelle within the nucleus. How the nucleolar structure is regulated is poorly understood. Here, we identified two types of nucleoli in C. elegans....
10.
Zhang H, Fan W, Nshogoza G, Liu Y, Gao J, Wu J, et al.
Biophys Rep
. 2023 Jun;
8(2):90-99.
PMID: 37287829
The assembly of biomolecular condensates is driven by liquid-liquid phase separation. To understand the structure and functions of these condensates, it is essential to characterize the underlying driving forces, ..,...