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Kazuya Hata

Explore the profile of Kazuya Hata including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 557
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Recent Articles
1.
Kuno T, Hata K, Takamatsu M, Hara A, Hirose Y, Takahashi S, et al.
Int J Mol Sci . 2014 May; 15(5):9160-72. PMID: 24857924
Activation of peroxisome proliferator-activated receptor (PPAR) α disrupts growth-related activities in a variety of human cancers. This study was designed to determine whether fenofibrate, a PPARα agonist, can suppress 4-nitroquinoline...
2.
Yoshimi K, Hashimoto T, Niwa Y, Hata K, Serikawa T, Tanaka T, et al.
BMC Cancer . 2012 Oct; 12:448. PMID: 23031214
Background: Chemotherapeutic bioassay for colorectal cancer (CRC) with a rat model bearing chemically-induced CRCs plays an important role in the development of new anti-tumor drugs and regimens. Although several protocols...
3.
Hatta K, Otachi T, Sudo Y, Kuga H, Takebayashi H, Hayashi H, et al.
Psychiatry Res . 2012 Mar; 198(2):194-201. PMID: 22421064
We examined whether augmentation with olanzapine would be superior to increased risperidone dose among acute schizophrenia patients showing early non-response to risperidone. We performed a rater-blinded, randomized controlled trial at...
4.
Hata K, Kubota M, Shimizu M, Moriwaki H, Kuno T, Tanaka T, et al.
Carcinogenesis . 2012 Jan; 33(3):702-7. PMID: 22223845
Obese people and diabetic patients are known to be high risk of colorectal cancer (CRC), suggesting need of a new preclinical animal model, by which to extensively study the diverse...
5.
Hata K, Kubota M, Shimizu M, Moriwaki H, Kuno T, Tanaka T, et al.
Int J Mol Sci . 2011 Dec; 12(11):8133-45. PMID: 22174655
The numbers of obese people and diabetic patients are ever increasing. Obesity and diabetes are high-risk conditions for chronic diseases, including certain types of cancer, such as colorectal cancer (CRC)....
6.
Hatano Y, Yamada Y, Hata K, Phutthaphadoong S, Aoki H, Hara A
Cancer Sci . 2011 Jun; 102(9):1659-64. PMID: 21668584
Colon carcinogenesis is a multistage process involving genetic alterations of various tumor suppressor genes and oncogenes. Repressor element 1 silencing factor (REST ), which was originally discovered as a transcriptional...
7.
Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, et al.
EMBO Mol Med . 2011 May; 3(6):320-33. PMID: 21542132
The stratum corneum (SC), the outermost layer of the epidermis, acts as a barrier against the external environment. It is hydrated by endogenous humectants to avoid desiccation. However, the molecular...
8.
Tomita H, Hirata A, Yamada Y, Hata K, Oyama T, Mori H, et al.
Carcinogenesis . 2010 Jul; 31(9):1627-33. PMID: 20622006
Global DNA hypomethylation and concomitant site-specific gene hypermethylation are among the most common molecular alterations in human neoplasia. Although site-specific DNA hypermethylation has been shown to be associated with the...
9.
Yasuda Y, Shimizu M, Shirakami Y, Sakai H, Kubota M, Hata K, et al.
Cancer Sci . 2010 Apr; 101(7):1701-7. PMID: 20398056
Obesity and related metabolic abnormalities are risk factors for colorectal cancer. A state of chronic inflammation and adipocytokine imbalance may play a role in colorectal carcinogenesis. Statins, which are commonly...
10.
Shimizu M, Shirakami Y, Iwasa J, Shiraki M, Yasuda Y, Hata K, et al.
Clin Cancer Res . 2009 Apr; 15(9):3068-75. PMID: 19366832
Purpose: Obesity and related metabolic abnormalities, including insulin resistance and activation of the insulin-like growth factor (IGF)/IGF-I receptor (IGF-IR) axis, are risk factors for colon cancer. Supplementation with branched-chain amino...