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Kazutoyo Abe

Explore the profile of Kazutoyo Abe including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 68
Followers 0
Related Specialties
Biochemistry
Pharmacology
Infectious Diseases
Top 10 Co-Authors
Toshiaki Sunazuka
Yoshihiro Watanabe
Masato Iwatsuki
Hidehito Matsui
Kazunari Sakai
Naoaki Arima
Hideaki Hanaki
Masako Honsho
Yukihiro Asami
Paul Wasuwanich
Published In
J Antibiot (Tokyo)
Biochim Biophys Acta
Bioorg Med Chem Lett
Affiliations
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Recent Articles
1.
Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499
Azami H, Watanabe Y, Sakai K, Nakahara H, Kojima H, Tokiwa T, et al.
J Antibiot (Tokyo) . 2024 Jan; 77(3):156-162. PMID: 38200163
A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound,...
2.
A combination strategy of a semisynthetic macrolide, 5-O-mycaminosyltylonolide with polymyxin B nonapeptide for multi-drug resistance P. aeruginosa
Kimishima A, Sakai K, Honsho M, Matsui H, Wasuwanich P, Watanabe Y, et al.
J Antibiot (Tokyo) . 2023 May; 76(8):499-501. PMID: 37208456
The emergence and spread of antimicrobial resistant pathogens continue to threaten our ability to combat several infections. Among them, Pseudomonas aeruginosa (P. aeruginosa) poses a major threat to human health....
3.
An efflux pump deletion mutant enabling the discovery of a macrolide as an overlooked anti-P. aeruginosa active compound
Kimishima A, Sakai K, Honsho M, Wasuwanich P, Matsui H, Watanabe Y, et al.
J Antibiot (Tokyo) . 2023 Mar; 76(5):301-303. PMID: 36964398
Antimicrobial resistance is a serious, worldwide problem. Pseudomonas aeruginosa (P. aeruginosa) is the pathogen that poses a major threat to human health. However, resistance-nodulation-cell division type multidrug efflux pump systems...
4.
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists
Yamazaki Y, Abe K, Toma T, Nishikawa M, Ozawa H, Okuda A, et al.
Bioorg Med Chem Lett . 2007 Jun; 17(16):4689-93. PMID: 17553678
A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor alpha (PPARalpha) agonist. The synthesis, structure-activity relationship (SAR)...
5.
Direct radical scavenging by the bisbenzylisoquinoline alkaloid cepharanthine
Kogure K, Tsuchiya K, Abe K, Akasu M, Tamaki T, Fukuzawa K, et al.
Biochim Biophys Acta . 2003 Jun; 1622(1):1-5. PMID: 12829254
Cepharanthine (Ceph) is known as a potent antiperoxidative agent. Recently, we characterized the antiperoxidative effects of Ceph [Biochim. Biophys. Acta 1426 (1999) 133]. However, it was not clear whether the...
6.
Mechanism of potent antiperoxidative effect of capsaicin
Kogure K, Goto S, Nishimura M, Yasumoto M, Abe K, Ohiwa C, et al.
Biochim Biophys Acta . 2002 Oct; 1573(1):84-92. PMID: 12383946
The effect of a pungent ingredient of red pepper, capsaicin, on lipid peroxidation of rat liver mitochondria (RLM) induced by ADP/Fe(2+) was studied. Capsaicin inhibited the lipid peroxidation significantly, being...