Antifungal Profile Against Candida Auris Clinical Isolates of Tyroscherin and Its New Analog Produced by the Deep-sea-derived Fungal Strain Scedosporium Apiospermum FKJ-0499

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 2024 Jan 10

PMID 38200163

Authors

Haruki Azami

Yoshihiro Watanabe

Kazunari Sakai

Hiroki Nakahara

Hiroki Kojima

Toshiyuki Tokiwa

Kenichi Nonaka

Yoshihiko Noguchi

Yuriko Nagano

Tomoyasu Hirose

Toshiaki Sunazuka

Hidehito Matsui

Naoaki Arima

Kazutoyo Abe

Hideaki Hanaki

Masato Iwatsuki

Affiliations

Soon will be listed here.

Abstract

A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2). The structure of 1 was elucidated as a new analog of 2 by MS and NMR analyses. The absolute configuration of 1 was determined by chemical derivatization. Both compounds showed potent in vitro antifungal activity against clinically isolated Candida auris strains, with MIC values ranging from 0.0625 to 4 µg ml.

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