Kazuko Sakai
Overview
Explore the profile of Kazuko Sakai including associated specialties, affiliations and a list of published articles.
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Articles
207
Citations
3153
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Recent Articles
1.
Aoki T, Nishida N, Kurebayashi Y, Sakai K, Fujiwara N, Tsurusaki M, et al.
Clin Mol Hepatol
. 2025 Mar;
PMID: 40065709
Background/aims: Previously, we advocated the importance of classifying hepatocellular carcinoma (HCC) based on physiological functions. This study aims to classify HCC by focusing on liver-intrinsic metabolism and glycolytic pathway in...
2.
Shiraishi N, Takahama T, Sakai K, Tanaka K, Nakagawa Y, Kanemura H, et al.
Thorac Cancer
. 2025 Feb;
16(3):e70007.
PMID: 39947926
Background: Recognizing rare molecular variants of driver mutations poses a challenge in precision oncology, particularly for treatment of non-small cell lung cancer (NSCLC). In this study, we aimed to determine...
3.
Kaneda H, Daga H, Okada A, Nakatani Y, Tani Y, Oka T, et al.
Invest New Drugs
. 2025 Jan;
43(1):147-156.
PMID: 39847172
Background: The RELAY-Brain trial examined the clinical utility and survival impacts of ramucirumab (RAM) combined with epidermal growth factor receptor (EGFR)-TKI in patients with EGFR-mutated non-small-cell lung cancer (NSCLC) with...
4.
Kenmotsu H, Sakai K, Mori K, Kato T, Sugawara S, Kirita K, et al.
JTO Clin Res Rep
. 2024 Oct;
5(11):100716.
PMID: 39399795
Introduction: EGFR tyrosine kinase inhibitors have been the standard treatment for patients with NSCLC who have sensitive mutations. This study revealed final analysis survival data, biomarkers, and resistance mechanisms of...
5.
Hata A, Katakami N, Takase N, Kibata K, Yamanaka Y, Tamiya M, et al.
Lung Cancer
. 2024 Oct;
197:107988.
PMID: 39393258
Introduction: Many clinical studies showed a synergy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) and vascular endothelial growth factor inhibitors. We hypothesized afatinib plus bevacizumab exerts clinical potency...
6.
Sakai K, Ohara S, Tanaka J, Suda K, Muramatsu T, Uematsu C, et al.
Cancer Sci
. 2024 Sep;
115(11):3795-3803.
PMID: 39308033
This study investigated the effectiveness of acoustic separation for platelet analysis in patients with non-small-cell lung cancer (NSCLC), comparing it with traditional centrifugation methods. In total, 10 patients with NSCLC...
7.
De Velasco M, Sakai K, Mitani S, Kura Y, Minamoto S, Haeno T, et al.
Int J Clin Oncol
. 2024 Sep;
29(12):1795-1810.
PMID: 39292320
Background: Genome DNA methylation profiling is a promising yet costly method for cancer classification, involving substantial data. We developed an ensemble learning model to identify cancer types using methylation profiles...
8.
Nagatani Y, Kiyota N, Imamura Y, Koyama T, Funakoshi Y, Komatsu M, et al.
Asia Pac J Clin Oncol
. 2024 Sep;
20(6):779-788.
PMID: 39233454
Aim: Although immune checkpoint inhibitors (ICPi) for salivary gland cancer (SGC) have been investigated in clinical trials, details of the tumor immune microenvironment (TIME) remain unclear. This research aimed to...
9.
Kura Y, De Velasco M, Sakai K, Uemura H, Fujita K, Nishio K
Hum Cell
. 2024 Aug;
37(6):1706-1718.
PMID: 39162974
Chronic systemic inflammation caused by diseases such as ulcerative colitis (UC) and Crohn's disease (CD) increases the risk of developing colorectal cancer (CRC). Recent evidence indicates that patients with UC...
10.
Wakamori C, De Velasco M, Sakai K, Kura Y, Matsushita M, Fujimoto S, et al.
Prostate
. 2024 Aug;
84(15):1375-1386.
PMID: 39113216
Background: Prostate cancer is a complex disease that develops over time and is influenced by several lifestyle factors that also impact gut microbes. Gut dysbiosis is intricately linked to prostate...