Kavitha Gowrishankar
Overview
Explore the profile of Kavitha Gowrishankar including associated specialties, affiliations and a list of published articles.
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24
Citations
755
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Recent Articles
1.
Gore S, Blyth E, Bleakley M, Lee K, Micklethwaite K, Gowrishankar K
Blood Adv
. 2025 Jan;
PMID: 39813621
T-cell receptor (TCR) therapies are a promising modality for the treatment of cancers, with significant efforts being directed towards acute myeloid leukaemia (AML), a particularly challenging disease. Chimeric antigen receptor...
2.
Louie R, Cai C, Samir J, Singh M, Deveson I, Ferguson J, et al.
Nat Commun
. 2023 Nov;
14(1):7767.
PMID: 38012187
Chimeric antigen receptor (CAR) T cell therapy is effective in treating B cell malignancies, but factors influencing the persistence of functional CAR T cells, such as product composition, patients' lymphodepletion,...
3.
York J, Gowrishankar K, Micklethwaite K, Palmer S, Cunningham A, Nasr N
Front Immunol
. 2022 May;
13:873701.
PMID: 35572509
Although the advent of ART has significantly reduced the morbidity and mortality associated with HIV infection, the stable pool of HIV in latently infected cells requires lifelong treatment adherence, with...
4.
Sutrave G, Xu N, Tang T, Dolnikov A, Gloss B, Gottlieb D, et al.
Mol Ther Methods Clin Dev
. 2022 Apr;
25:250-263.
PMID: 35474955
Chimeric antigen receptor (CAR) T cells targeting CD19 have demonstrated remarkable efficacy in the treatment of B cell malignancies. Current CAR T cell manufacturing protocols are complex and costly due...
5.
Micklethwaite K, Gowrishankar K, Gloss B, Li Z, Street J, Moezzi L, et al.
Blood
. 2021 May;
138(16):1391-1405.
PMID: 33974080
We performed a phase 1 clinical trial to evaluate outcomes in patients receiving donor-derived CD19-specific chimeric antigen receptor (CAR) T cells for B-cell malignancy that relapsed or persisted after matched...
6.
Lee K, Gowrishankar K, Street J, McGuire H, Luciani F, Hughes B, et al.
Clin Transl Immunology
. 2020 Oct;
9(10):e1200.
PMID: 33101678
Objective: Adoptive immunotherapy with expanded tumor-specific T cells has potential as anticancer therapy. Preferentially expressed antigen in melanoma (PRAME) is an attractive target overexpressed in several cancers including melanoma and...
7.
Habib R, Nagrial A, Micklethwaite K, Gowrishankar K
Adv Exp Med Biol
. 2020 Jun;
1263:117-143.
PMID: 32588326
Chimeric antigen receptor T (CAR-T) cell therapy has dramatically revolutionised cancer treatment. The FDA approval of two CAR-T cell products for otherwise incurable refractory B-cell acute lymphoblastic leukaemia (B-ALL) and...
8.
Bishop D, Caproni L, Gowrishankar K, Legiewicz M, Karbowniczek K, Tite J, et al.
Mol Ther Methods Clin Dev
. 2020 Feb;
17:359-368.
PMID: 32071928
CD19-specific chimeric antigen receptor (CAR19) T cells, generated using viral vectors, are an efficacious but costly treatment for B cell malignancies. The nonviral transposon system provides a simple and inexpensive...
9.
Hersey P, Kakavand H, Wilmott J, van der Westhuizen A, Gallagher S, Gowrishankar K, et al.
Melanoma Manag
. 2018 Sep;
1(2):165-172.
PMID: 30190821
The introduction of immunotherapy based on the blockade of the PD1/PD-L1 checkpoints has been associated with high response rates and durable remissions of disease in patients with metastatic melanoma, to...
10.
Gowrishankar K, Birtwistle L, Micklethwaite K
Mamm Genome
. 2018 Jul;
29(11-12):739-756.
PMID: 29987406
T-cells expressing synthetic chimeric antigen receptors (CARs) have revolutionized immuno-oncology and highlighted the use of adoptive cell transfer, for the treatment of cancer. The phenomenal clinical success obtained in the...