Richard F Kefford
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Explore the profile of Richard F Kefford including associated specialties, affiliations and a list of published articles.
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139
Citations
10296
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Recent Articles
1.
Ming Z, Lim S, Stewart A, Pedersen B, Shklovskaya E, Menzies A, et al.
J Invest Dermatol
. 2023 Feb;
143(7):1246-1256.e8.
PMID: 36736995
Immunotherapy targeting PD-1 and/or CTLA4 leads to durable responses in a proportion of patients with melanoma. However, many patients will not respond to these immune checkpoint inhibitors, and up to...
2.
Hong A, Waldstein C, Shivalingam B, Carlino M, Atkinson V, Kefford R, et al.
Eur J Cancer
. 2020 Nov;
142:10-17.
PMID: 33207293
Introduction: The brain is a common site of metastatic disease for patients with advanced melanoma. Brain metastasis portends a poor prognosis, often causing deterioration in neurological function and quality of...
3.
Shklovskaya E, Lee J, Lim S, Stewart A, Pedersen B, Ferguson P, et al.
Cancers (Basel)
. 2020 Nov;
12(11).
PMID: 33202676
Immunotherapy targeting T-cell inhibitory receptors, namely programmed cell death-1 (PD-1) and/or cytotoxic T-lymphocyte associated protein-4 (CTLA-4), leads to durable responses in a proportion of patients with advanced metastatic melanoma. Combination...
4.
Diefenbach R, Lee J, Menzies A, Carlino M, Long G, Saw R, et al.
Cancers (Basel)
. 2020 Aug;
12(8).
PMID: 32785074
Detection of melanoma-associated mutations using circulating tumor DNA (ctDNA) from plasma is a potential alternative to using genomic DNA from invasive tissue biopsies. In this study, we developed a custom...
5.
Lee J, Menzies A, Carlino M, McEvoy A, Sandhu S, Weppler A, et al.
Clin Cancer Res
. 2020 Apr;
26(15):4064-4071.
PMID: 32321716
Purpose: Brain involvement occurs in the majority of patients with metastatic melanoma. The potential of circulating tumor DNA (ctDNA) for surveillance and monitoring systemic therapy response in patients with melanoma...
6.
Lee J, Shklovskaya E, Lim S, Carlino M, Menzies A, Stewart A, et al.
Nat Commun
. 2020 Apr;
11(1):1897.
PMID: 32312968
Transcriptomic signatures designed to predict melanoma patient responses to PD-1 blockade have been reported but rarely validated. We now show that intra-patient heterogeneity of tumor responses to PD-1 inhibition limit...
7.
Diefenbach R, Lee J, Strbenac D, Yang J, Menzies A, Carlino M, et al.
Cancers (Basel)
. 2019 Dec;
11(12).
PMID: 31795494
The use of circulating tumor DNA (ctDNA) to monitor cancer progression and response to therapy has significant potential but there is only limited data on whether this technique can detect...
8.
Ming Z, Lim S, Kefford R, Rizos H
Pigment Cell Melanoma Res
. 2019 Sep;
33(2):345-357.
PMID: 31518489
Inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway and immune checkpoint molecules have dramatically improved the survival of patients with BRAF -mutant melanoma. For BRAF/RAS wild-type (WT) melanoma patients, however,...
9.
Long G, Saw R, Lo S, Nieweg O, Shannon K, Gonzalez M, et al.
Lancet Oncol
. 2019 Jun;
20(7):961-971.
PMID: 31171444
Background: Adjuvant dabrafenib plus trametinib therapy improves relapse-free survival in patients with resected stage III melanoma. We aimed to ascertain the proportion of patients who would have a pathological response...
10.
Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K -Mutant Melanoma
Pires da Silva I, Wang K, Wilmott J, Holst J, Carlino M, Park J, et al.
Clin Cancer Res
. 2019 Jan;
25(4):1272-1279.
PMID: 30630828
Purpose: V600E and V600K melanomas have distinct clinicopathologic features, and V600K appear to be less responsive to ±. We investigated mechanisms for this and explored whether genotype affects response to...