Katrina Gwinn
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Explore the profile of Katrina Gwinn including associated specialties, affiliations and a list of published articles.
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32
Citations
2417
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Recent Articles
1.
Chaudhuri S, Ben Chaouch Z, Hauber B, Mange B, Zhou M, Christopher S, et al.
J Biopharm Stat
. 2023 Mar;
:1-20.
PMID: 36861942
A fixed one-sided significance level of 5% is commonly used to interpret the statistical significance of randomized clinical trial (RCT) outcomes. While it is necessary to reduce the false positive...
2.
Benz H, Caldwell B, Ruiz J, Saha A, Ho M, Christopher S, et al.
MDM Policy Pract
. 2021 Jul;
6(1):23814683211021380.
PMID: 34277950
A growing literature has developed on identifying outcomes that matter to patients. This study demonstrates an approach involving patient and regulatory perspectives to identify outcomes that are meaningful in the...
3.
Hauber B, Mange B, Zhou M, Chaudhuri S, Benz H, Caldwell B, et al.
MDM Policy Pract
. 2021 Feb;
6(1):2381468320978407.
PMID: 33521289
Parkinson's disease (PD) is neurodegenerative, causing motor, cognitive, psychological, somatic, and autonomic symptoms. Understanding PD patients' preferences for novel neurostimulation devices may help ensure that devices are delivered in a...
4.
Marjenin T, Scott P, Bajaj A, Bansal T, Berne B, Bowsher K, et al.
Neuromodulation
. 2020 Jan;
23(1):3-9.
PMID: 31965667
The United States Food and Drug Administration (FDA) ensures that patients in the United States have access to safe and effective medical devices. The division of neurological and physical medicine...
5.
Chen-Plotkin A, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, et al.
Sci Transl Med
. 2018 Aug;
10(454).
PMID: 30111645
The recent advent of an "ecosystem" of shared biofluid sample biorepositories and data sets will focus biomarker efforts in Parkinson's disease, boosting the therapeutic development pipeline and enabling translation with...
6.
Goldman J, Andrews H, Amara A, Naito A, Alcalay R, Shaw L, et al.
Mov Disord
. 2017 Dec;
33(2):282-288.
PMID: 29205509
Objective: Examine relationships among neurodegenerative biomarkers and PD motor and nonmotor symptoms. Background: CSF alpha-synuclein is decreased in PD versus healthy controls, but whether plasma and saliva alpha-synuclein differentiate these...
7.
Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, et al.
Sci Rep
. 2017 Aug;
7(1):9003.
PMID: 28827786
To examine the pathogenic role of α-synuclein (αS) in Parkinson's Disease, we have generated induced Pluripotent Stem Cell lines from early onset Parkinson's Disease patients with SNCA A53T and SNCA...
8.
Gwinn K, David K, Swanson-Fischer C, Albin R, St Hillaire-Clarke C, Sieber B, et al.
Biomark Med
. 2017 Jun;
11(6):451-473.
PMID: 28644039
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders...
9.
Hopfner F, Haubenberger D, Galpern W, Gwinn K, Vant Veer A, White S, et al.
Parkinsonism Relat Disord
. 2016 Oct;
33:27-35.
PMID: 27769649
Essential tremor (ET) is a common cause of significant disability, but its etiologies and pathogenesis are poorly understood. Research has been hampered by the variable definition of ET and by...
10.
Kang U, Goldman J, Alcalay R, Xie T, Tuite P, Henchcliffe C, et al.
Mov Disord
. 2016 Apr;
31(6):924-32.
PMID: 27113479
Background: Identifying PD-specific biomarkers in biofluids will greatly aid in diagnosis, monitoring progression, and therapeutic interventions. PD biomarkers have been limited by poor discriminatory power, partly driven by heterogeneity of...