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Kathryn J Brayer

Explore the profile of Kathryn J Brayer including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 446
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Recent Articles
1.
Myers B, Brayer K, Paez-Beltran L, Villicana E, Keith M, Suzuki H, et al.
Nat Commun . 2024 Nov; 15(1):10363. PMID: 39609428
Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors driven by complex genetic alterations. The basic-helix-loop-helix (bHLH) transcription factors ASCL1 and OLIG2 are dynamically co-expressed in GBMs; however, their...
2.
Brayer K, Hanson J, Cingam S, Martinez C, Ness S, Rabinowitz I
PLoS One . 2023 Nov; 18(11):e0284232. PMID: 37910468
Pancreatic ductal adenocarcinoma (PDAC) is a poor prognosis cancer with an aggressive growth profile that is often diagnosed at late stage and that has few curative or therapeutic options. PDAC...
3.
Myers B, Brayer K, Paez-Beltran L, Keith M, Suzuki H, Newville J, et al.
bioRxiv . 2023 Oct; PMID: 37873200
Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors driven by complex driver mutations and glioma stem cells (GSCs). The neurodevelopmental transcription factors ASCL1 and OLIG2 are co-expressed in...
4.
Anderson J, Morin E, Brayer K, Salbato S, Gonzalez Bosc L, Kanagy N, et al.
Physiol Genomics . 2023 Mar; 55(4):179-193. PMID: 36912534
The endothelium contains morphologically similar cells throughout the vasculature, but individual cells along the length of a single vascular tree or in different regional circulations function dissimilarly. When observations made...
5.
Brayer K, Kang H, El-Naggar A, Andreasen S, Homoe P, Kiss K, et al.
Cancers (Basel) . 2023 Mar; 15(5). PMID: 36900183
Adenoid cystic carcinoma (ACC) is an aggressive malignancy that most often arises in salivary or lacrimal glands but can also occur in other tissues. We used optimized RNA-sequencing to analyze...
6.
Steinkamp M, Lagutina I, Brayer K, Schultz F, Burke D, Pankratz V, et al.
Cancer Res Commun . 2023 Mar; 3(2):309-324. PMID: 36860657
Significance: huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the...
7.
Pauken C, Kenney S, Brayer K, Guo Y, Brown-Glaberman U, Marchetti D
Cancers (Basel) . 2021 Oct; 13(19). PMID: 34638368
Fatal metastasis occurs when circulating tumor cells (CTCs) disperse through the blood to initiate a new tumor at specific sites distant from the primary tumor. CTCs have been classically defined...
8.
Grimes M, Kenney S, Dominguez D, Brayer K, Guo Y, Wandinger-Ness A, et al.
BMC Cancer . 2021 Jan; 21(1):40. PMID: 33413202
Background: Rho-family GTPases, including Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), are important modulators of cancer-relevant cell functions and are viewed as promising...
9.
Lee D, Brayer K, Mitani Y, Burns E, Rao P, Bell D, et al.
Cancers (Basel) . 2020 Sep; 12(9). PMID: 32867110
Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. However, little is known about how...
10.
Frerich C, Brayer K, Painter B, Kang H, Mitani Y, El-Naggar A, et al.
Oncotarget . 2018 Feb; 9(7):7341-7358. PMID: 29484115
The relative rarity of salivary gland adenoid cystic carcinoma (ACC) and its slow growing yet aggressive nature has complicated the development of molecular markers for patient stratification. To analyze molecular...