Katherine S Pawelczak
Overview
Explore the profile of Katherine S Pawelczak including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
748
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0
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Recent Articles
1.
Mendoza-Munoz P, Gavande N, VanderVere-Carozza P, Pawelczak K, Dynlacht J, Garrett J, et al.
NAR Cancer
. 2023 Feb;
5(1):zcad003.
PMID: 36755959
The DNA-dependent protein kinase (DNA-PK) plays a critical role in the DNA damage response (DDR) and non-homologous end joining (NHEJ) double-strand break (DSB) repair pathways. Consequently, DNA-PK is a validated...
2.
Turchi J, Pawelczak K, Weinfeld M, McHugh P
Front Oncol
. 2022 Oct;
12:1023500.
PMID: 36237323
No abstract available.
3.
Kelm J, Samarbakhsh A, Pillai A, VanderVere-Carozza P, Aruri H, Pandey D, et al.
Front Oncol
. 2022 Apr;
12:850883.
PMID: 35463312
The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR) during their course of treatment, yet the efficacy of these therapies is tempered by DNA repair and...
4.
VanderVere-Carozza P, Gavande N, Jalal S, Pollok K, Ekinci E, Heyza J, et al.
Front Oncol
. 2022 Mar;
12:826655.
PMID: 35251993
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as...
5.
Cong K, Peng M, Nedergaard Kousholt A, Lee W, Lee S, Nayak S, et al.
Mol Cell
. 2021 Aug;
81(15):3227.
PMID: 34358459
No abstract available.
6.
Par S, Vaides S, VanderVere-Carozza P, Pawelczak K, Stewart J, Turchi J
Cancers (Basel)
. 2021 Jul;
13(13).
PMID: 34283091
Genome stability and maintenance pathways along with their requisite proteins are critical for the accurate duplication of genetic material, mutation avoidance, and suppression of human diseases including cancer. Many of...
7.
Cong K, Peng M, Nedergaard Kousholt A, Lee W, Lee S, Nayak S, et al.
Mol Cell
. 2021 Jul;
81(15):3128-3144.e7.
PMID: 34216544
Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly(ADP-ribose) polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded breaks (DSBs) necessitating BRCA function in homologous recombination...
8.
Gavande N, VanderVere-Carozza P, Pawelczak K, Mendoza-Munoz P, Vernon T, Hanakahi L, et al.
Nucleic Acids Res
. 2020 Oct;
48(20):11536-11550.
PMID: 33119767
DNA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) repair pathway and the DNA damage response (DDR). DNA-PK has therefore been pursued for the development...
9.
Sriramkumar S, Matthews T, Ghobashi A, Miller S, VanderVere-Carozza P, Pawelczak K, et al.
Mol Cancer Res
. 2020 Aug;
18(11):1699-1710.
PMID: 32801161
Platinum resistance is a common occurrence in high-grade serous ovarian cancer and a major cause of ovarian cancer deaths. Platinum agents form DNA cross-links, which activate nucleotide excision repair (NER),...
10.
Gavande N, VanderVere-Carozza P, Pawelczak K, Vernon T, Jordan M, Turchi J
ACS Med Chem Lett
. 2020 Jun;
11(6):1118-1124.
PMID: 32550990
Replication protein A (RPA) is the major human single stranded DNA (ssDNA)-binding protein, playing essential roles in DNA replication, repair, recombination, and DNA-damage response (DDR). Inhibition of RPA-DNA interactions represents...