Katherine E Pinnick
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Explore the profile of Katherine E Pinnick including associated specialties, affiliations and a list of published articles.
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24
Citations
1113
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Recent Articles
1.
Cresswell E, Basty N, Atabaki Pasdar N, Karpe F, Pinnick K
Biochem Pharmacol
. 2024 Mar;
223:116171.
PMID: 38552854
Upper-body adiposity is adversely associated with metabolic health whereas the opposite is observed for the lower-body. The neck is a unique upper-body fat depot in adult humans, housing thermogenic brown...
2.
Gamwell J, Paphiti K, Hodson L, Karpe F, Pinnick K, Todorcevic M
Adipocyte
. 2023 Feb;
12(1):2179339.
PMID: 36763512
While there is no standardized protocol for the differentiation of human adipocytes in culture, common themes exist in the use of supra-physiological glucose and hormone concentrations, and an absence of...
3.
Kuo F, Neville M, Sabaratnam R, Wesolowska-Andersen A, Phillips D, Wittemans L, et al.
Cell Rep
. 2022 Jul;
40(4):111136.
PMID: 35905723
Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where...
4.
Green C, Marjot T, Walsby-Tickle J, Charlton C, Cornfield T, Westcott F, et al.
Eur J Endocrinol
. 2022 Jan;
186(3):367-377.
PMID: 35038311
Objective: Metformin is a first-line pharmacotherapy in the treatment of type 2 diabetes, a condition closely associated with non-alcoholic fatty liver disease (NAFLD). Although metformin promotes weight loss and improves...
5.
Akbar N, Pinnick K, Paget D, Choudhury R
J Vis Exp
. 2021 May;
(170).
PMID: 33938882
Extracellular vesicles (EVs) are lipid enclosed envelopes that carry biologically active material such as proteins, RNA, metabolites and lipids. EVs can modulate the cellular status of other cells locally in...
6.
Gunn P, Pramfalk C, Millar V, Cornfield T, Hutchinson M, Johnson E, et al.
Physiol Rep
. 2020 Jul;
8(13):e14482.
PMID: 32643289
Background And Aims: Nonalcoholic fatty liver disease (NAFLD) begins with steatosis, where a mixed macrovesicular pattern of large and small lipid droplets (LDs) develops. Since in vitro models recapitulating this...
7.
Loh N, Minchin J, Pinnick K, Verma M, Todorcevic M, Denton N, et al.
Nat Commun
. 2020 Jun;
11(1):2797.
PMID: 32493999
Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with...
8.
Lord S, Collins J, Cheng W, Haider S, Wigfield S, Gaude E, et al.
Br J Cancer
. 2019 Dec;
122(2):258-265.
PMID: 31819193
Background: Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are...
9.
Denton N, Eghleilib M, Al-Sharifi S, Todorcevic M, Neville M, Loh N, et al.
Int J Obes (Lond)
. 2019 Oct;
43(12):2593.
PMID: 31641215
We erroneously published the original Article with an incorrect Copyright line. This has been updated in the XML, PDF and HTML versions of this Article.
10.
Denton N, Eghleilib M, Al-Sharifi S, Todorcevic M, Neville M, Loh N, et al.
Int J Obes (Lond)
. 2019 Jul;
43(12):2458-2468.
PMID: 31324879
Background: Bone morphogenetic proteins (BMPs) regulate adipogenesis but it is not clear whether they influence regional adipose tissue (AT) development in humans. Objective: To characterise BMP2 expression, BMP2-SMAD1/5/8 signalling, and...