Katherine C MacNamara
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Explore the profile of Katherine C MacNamara including associated specialties, affiliations and a list of published articles.
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40
Citations
820
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Recent Articles
11.
Howard J, Smith J, Fredman G, MacNamara K
Stem Cell Reports
. 2021 Nov;
16(12):2887-2899.
PMID: 34798063
Severe infection can dramatically alter blood production, but the mechanisms driving hematopoietic stem and progenitor cell (HSC/HSPC) loss have not been clearly defined. Using Ixodes ovatus Ehrlichia (IOE), a tick-borne...
12.
Fredman G, MacNamara K
Cardiovasc Res
. 2021 Oct;
117(13):2563-2574.
PMID: 34609505
The resolution of inflammation (or inflammation-resolution) is an active and highly coordinated process. Inflammation-resolution is governed by several endogenous factors, and specialized pro-resolving mediators (SPMs) are one such class of...
13.
Sadhu S, Decker C, Sansbury B, Marinello M, Seyfried A, Howard J, et al.
J Immunol
. 2021 Aug;
207(7):1812-1823.
PMID: 34462312
Radiation is associated with tissue damage and increased risk of atherosclerosis, but there are currently no treatments and a very limited mechanistic understanding of how radiation impacts tissue repair mechanisms....
14.
Seyfried A, McCabe A, Smith J, Calvi L, MacNamara K
Leukemia
. 2021 Mar;
35(11):3139-3151.
PMID: 33744909
Severe aplastic anemia (SAA) is an acquired, T cell-driven bone marrow (BM) failure disease characterized by elevated interferon gamma (IFNγ), loss of hematopoietic stem cells (HSCs), and altered BM microenvironment,...
15.
Seyfried A, Maloney J, MacNamara K
Front Immunol
. 2020 Aug;
11:1499.
PMID: 32849512
The bone marrow contains distinct cell types that work in coordination to generate blood and immune cells, and it is the primary residence of hematopoietic stem cells (HSCs) and more...
16.
Rymut N, Heinz J, Sadhu S, Hosseini Z, Riley C, Marinello M, et al.
FASEB J
. 2020 Jan;
34(1):597-609.
PMID: 31914705
Inflammation-resolution is mediated by the balance between specialized pro-resolving mediators (SPMs) like resolvin D1 (RvD1) and pro-inflammatory factors, like leukotriene B (LTB). A key cellular process of inflammation-resolution is efferocytosis....
17.
Frisch B, Hoffman C, Latchney S, LaMere M, Myers J, Ashton J, et al.
JCI Insight
. 2019 Apr;
5.
PMID: 30998506
The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction...
18.
Smith J, Zhang Y, Li J, McCabe A, Jo H, Maloney J, et al.
PLoS Pathog
. 2018 Aug;
14(8):e1007234.
PMID: 30080899
Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe...
19.
McCabe A, Smith J, Costello A, Maloney J, Katikaneni D, MacNamara K
Haematologica
. 2018 May;
103(9):1451-1461.
PMID: 29773597
Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying mechanisms driving hematopoietic stem...
20.