Katharine E McCann
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Explore the profile of Katharine E McCann including associated specialties, affiliations and a list of published articles.
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Citations
434
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Recent Articles
1.
Radzicki D, McCann K, Alexander G, Dudek S
Mol Psychiatry
. 2024 Nov;
PMID: 39548322
Neuronal activity in the hippocampus is critical for many types of memory acquisition and retrieval and influences an animal's response to stress. Moreover, the molecularly distinct principal neurons of hippocampal...
2.
Petersen N, McCann K, Stavarache M, Kim L, Weinshenker D, Winder D
Biol Psychiatry
. 2024 Oct;
PMID: 39419462
Background: Sleep and arousal disorders are common, but the underlying physiology of wakefulness is not fully understood. The locus coeruleus promotes arousal via α-adrenergic receptor (αAR)-driven recruitment of wake-promoting dopamine...
3.
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Goettemoeller A, Banks E, Kumar P, Olah V, McCann K, South K, et al.
Nat Commun
. 2024 Sep;
15(1):7918.
PMID: 39256379
Preventative treatment for Alzheimer's Disease (AD) is dire, yet mechanisms underlying early regional vulnerability remain unknown. In AD, one of the earliest pathophysiological correlates to cognitive decline is hyperexcitability, which...
4.
Jones S, Sleiman S, McCann K, Jarmusch A, Alexander G, Dudek S
Neuropsychopharmacology
. 2024 Sep;
50(2):378-387.
PMID: 39237618
In the brain, the hippocampus is enriched with mineralocorticoid receptors (MR; Nr3c2), a ligand-dependent transcription factor stimulated by the stress hormone corticosterone in rodents. Recently, we discovered that MR is...
5.
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Goettemoeller A, Banks E, Kumar P, Olah V, McCann K, South K, et al.
bioRxiv
. 2024 Jul;
PMID: 39005389
Preventative treatment for Alzheimer's Disease is of dire importance, and yet, cellular mechanisms underlying early regional vulnerability in Alzheimer's Disease remain unknown. In human patients with Alzheimer's Disease, one of...
6.
Liu J, Lustberg D, Galvez A, Liles L, McCann K, Weinshenker D
Neurobiol Stress
. 2024 Feb;
29:100612.
PMID: 38371489
In rodents, exposure to predator odors such as cat urine acts as a severe stressor that engages innate defensive behaviors critical for survival in the wild. The neurotransmitters norepinephrine (NE)...
7.
Liu J, Lustberg D, Galvez A, Liles L, McCann K, Weinshenker D
bioRxiv
. 2024 Jan;
PMID: 38234825
In rodents, exposure to predator odors such as cat urine acts as a severe stressor that engages innate defensive behaviors critical for survival in the wild. The neurotransmitters norepinephrine (NE)...
8.
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Goettemoeller A, Banks E, McCann K, Kumar P, South K, Olah V, et al.
Res Sq
. 2023 Nov;
PMID: 37987015
Preventative treatment for Alzheimer's Disease is of dire importance, and yet, cellular mechanisms underlying early regional vulnerability in Alzheimer's Disease remain unknown. In human patients with Alzheimer's Disease, one of...
9.
Iannitelli A, Hassenein L, Mulvey B, Blankenship H, Liles L, Sharpe A, et al.
bioRxiv
. 2023 Mar;
PMID: 36945637
The locus coeruleus (LC), the major source of norepinephrine (NE) in the brain, is an early site of pathology in both Alzheimer's disease (AD) and Parkinson's disease (PD), and it...
10.
Kelberman M, Rorabaugh J, Anderson C, Marriott A, DePuy S, Rasmussen K, et al.
Neurobiol Aging
. 2023 Mar;
125:98-108.
PMID: 36889122
Hyperphosphorylated tau in the locus coeruleus (LC) is ubiquitous in prodromal Alzheimer's disease (AD), and LC neurons degenerate as AD progresses. Hyperphosphorylated tau alters firing rates in other brain regions,...