Katharina Hotte
Overview
Explore the profile of Katharina Hotte including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
301
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0
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Recent Articles
1.
Gebel J, Tuppi M, Chaikuad A, Hotte K, Schroder M, Schulz L, et al.
Nat Chem Biol
. 2020 Jul;
16(10):1078-1086.
PMID: 32719556
The p53 homolog TAp63α is the transcriptional key regulator of genome integrity in oocytes. After DNA damage, TAp63α is activated by multistep phosphorylation involving multiple phosphorylation events by the kinase...
2.
Hotte K, Koch M, Hof L, Tuppi M, Moreth T, Verstegen M, et al.
Sci Rep
. 2019 Nov;
9(1):17292.
PMID: 31754183
In three-dimensional light microscopy, the heterogeneity of the optical density in a specimen ultimately limits the achievable penetration depth and hence the three-dimensional resolution. The most direct approach to reduce...
3.
Tuppi M, Kehrloesser S, Coutandin D, Rossi V, Luh L, Strubel A, et al.
Nat Struct Mol Biol
. 2018 Feb;
25(3):261-269.
PMID: 29483652
The survival rate of cancer patients is steadily increasing, owing to more efficient therapies. Understanding the molecular mechanisms of chemotherapy-induced premature ovarian insufficiency (POI) could identify targets for prevention of...
4.
Hotte K, Smyrek I, Starzinski-Powitz A, Stelzer E
Biol Open
. 2017 May;
6(6):723-731.
PMID: 28483980
The adherens junction associated protein 1 (AJAP1, aka shrew-1) is presumably a type-I transmembrane protein localizing and interacting with the E-cadherin-catenin complex. In various tumors, AJAP1 expression is reduced or...
5.
van Wijk S, Fricke F, Herhaus L, Gupta J, Hotte K, Pampaloni F, et al.
Nat Microbiol
. 2017 May;
2:17066.
PMID: 28481361
Ubiquitination of invading Salmonella Typhimurium triggers autophagy of cytosolic bacteria and restricts their spread in epithelial cells. Ubiquitin (Ub) chains recruit autophagy receptors such as p62/SQSTM1, NDP52/CALCOCO and optineurin (OPTN),...
6.
Pampaloni F, Mayer B, Kabat Vel-Job K, Ansari N, Hotte K, Kogel D, et al.
SLAS Discov
. 2017 Mar;
22(5):558-570.
PMID: 28297606
Dysregulation of the basal autophagic flux has been linked to several pathological conditions, including neurodegenerative diseases and cancer. In addition, autophagy has profound effects on the response of tumor cells...
7.
Wilmes S, Beutel O, Li Z, Francois-Newton V, Richter C, Janning D, et al.
J Cell Biol
. 2015 May;
209(4):579-93.
PMID: 26008745
Type I interferons (IFNs) activate differential cellular responses through a shared cell surface receptor composed of the two subunits, IFNAR1 and IFNAR2. We propose here a mechanistic model for how...
8.
Ansari N, Hardung S, Hotte K, Rakel S, Antonietti P, Kogel D, et al.
Methods Mol Biol
. 2014 May;
1165:19-29.
PMID: 24839016
We present a 3D assay for the quantification of the autophagic flux in live cell spheroids by using the fluorescent reporter mRFP-GFP-LC3. The protocol describes the formation of the spheroids...