Katharina Flach
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Explore the profile of Katharina Flach including associated specialties, affiliations and a list of published articles.
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7
Citations
245
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Recent Articles
1.
Lewczuk P, Lelental N, Lachmann I, Holzer M, Flach K, Brandner S, et al.
J Alzheimers Dis
. 2016 Sep;
55(1):159-170.
PMID: 27662295
Background: Virtually nothing is known about a potential diagnostic role of non-phospho-epitopes of Tau (Non-P-Tau) in cerebrospinal fluid (CSF). Objective: To establish and analytically and clinically characterize the first assay...
2.
Herrmann L, Wiegmann C, Arsalan-Werner A, Hilbrich I, Jager C, Flach K, et al.
PLoS One
. 2015 Mar;
10(3):e0119423.
PMID: 25799409
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study...
3.
Morawski M, Dityatev A, Hartlage-Rubsamen M, Blosa M, Holzer M, Flach K, et al.
Philos Trans R Soc Lond B Biol Sci
. 2014 Sep;
369(1654):20140046.
PMID: 25225104
Perineuronal nets (PNs) in the brains of tenascin-R-deficient (tn-r(-/-)) mice develop in temporal concordance with those of wild-type (tn-r(+/+)) mice. However, the histological appearance of PNs is abnormal in adult...
4.
Unterberger U, Lachmann I, Voigtlander T, Pirker W, Berghoff A, Flach K, et al.
Clin Neuropathol
. 2014 Aug;
33(5):329-34.
PMID: 25131945
With the aim to evaluate the significance and reliability of detecting disease-specific α-synuclein in the cerebrospinal fluid (CSF) we developed an ELISA and bead-assay. We used a commercial antibody (5G4)...
5.
Flach K, Ramminger E, Hilbrich I, Arsalan-Werner A, Albrecht F, Herrmann L, et al.
Biochim Biophys Acta
. 2014 Jun;
1842(9):1527-38.
PMID: 24905733
Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and...
6.
Flach K, Hilbrich I, Schiffmann A, Gartner U, Kruger M, Leonhardt M, et al.
J Biol Chem
. 2012 Nov;
287(52):43223-33.
PMID: 23129775
The microtubule-associated protein Tau is mainly expressed in neurons, where it binds and stabilizes microtubules. In Alzheimer disease and other tauopathies, Tau protein has a reduced affinity toward microtubules. As...
7.
Kuhla B, Haase C, Flach K, Luth H, Arendt T, Munch G
J Biol Chem
. 2006 Nov;
282(10):6984-91.
PMID: 17082178
Accumulation of hyperphosphorylated Tau protein as paired helical filaments in pyramidal neurons is a major hallmark of Alzheimer disease. Besides hyperphosphorylation, other modifications of the Tau protein, such as cross-linking,...