Kaspar Keledjian
Overview
Explore the profile of Kaspar Keledjian including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
497
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Recent Articles
1.
Shim B, Ciryam P, Tosun C, Serra R, Tsymbalyuk N, Keledjian K, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39796165
Brain ischemia causes disruption in cerebral blood flow and blood-brain barrier integrity, which are normally maintained by astrocyte endfeet. Emerging evidence points to dysregulation of the astrocyte translatome during ischemia,...
2.
Shim B, Ciryam P, Tosun C, Serra R, Tsymbalyuk N, Keledjian K, et al.
bioRxiv
. 2024 Oct;
PMID: 39416227
Brain ischemia causes disruption in cerebral blood flow and blood-brain barrier (BBB) integrity which are normally maintained by the astrocyte endfeet. Emerging evidence points to dysregulation of the astrocyte translatome...
3.
Zhang C, Gerzanich V, Cruz-Cosme R, Zhang J, Tsymbalyuk O, Tosun C, et al.
mBio
. 2024 Sep;
15(11):e0230824.
PMID: 39345136
Importance: The major challenge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the pandemic is COVID-19-related mortality, which has tragically claimed millions of lives. COVID-19-associated morbidity and mortality...
4.
Simard J, Tosun C, Tsymbalyuk O, Moyer M, Keledjian K, Tsymbalyuk N, et al.
J Neurotrauma
. 2024 Sep;
42(1-2):143-160.
PMID: 39302058
Trauma to the brain can induce a contusion characterized by a discrete intracerebral or diffuse interstitial hemorrhage. In humans, "computed tomography-positive," that is, hemorrhagic, temporal lobe contusions (tlCont) have unique...
5.
Simard J, Wilhelmy B, Tsymbalyuk N, Shim B, Stokum J, Evans M, et al.
Brain Sci
. 2024 Mar;
14(3).
PMID: 38539619
In human stroke, brain swelling is an important predictor of neurological outcome and mortality, yet treatments to reduce or prevent brain swelling are extremely limited, due in part to an...
6.
Shim B, Stokum J, Moyer M, Tsymbalyuk N, Tsymbalyuk O, Keledjian K, et al.
Cells
. 2023 Sep;
12(18).
PMID: 37759444
Brain swelling is a major cause of death and disability in ischemic stroke. Drugs of the gliflozin class, which target the Na-coupled D-glucose cotransporter, SGLT2, are approved for type 2...
7.
Keledjian K, Makar T, Zhang C, Zhang J, Shim B, Davis H, et al.
J Clin Med
. 2023 Aug;
12(16).
PMID: 37629211
Over 38 million people worldwide are living with HIV/AIDS, and more than half of them are affected by HIV-associated neurocognitive disorders (HAND). Such disorders are characterized by chronic neuroinflammation, neurotoxicity,...
8.
Stokum J, Shim B, Negoita S, Tsymbalyuk N, Tsymbalyuk O, Ivanova S, et al.
Sci Signal
. 2023 Jun;
16(788):eadd6364.
PMID: 37279286
Brain swelling causes morbidity and mortality in various brain injuries and diseases but lacks effective treatments. Brain swelling is linked to the influx of water into perivascular astrocytes through channels...
9.
Makar T, Guda P, Ray S, Andhavarapu S, Keledjian K, Gerzanich V, et al.
Sci Rep
. 2023 Apr;
13(1):5635.
PMID: 37024509
Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are found in lesions of multiple sclerosis (MS) and animal models of MS such as experimental autoimmune encephalomyelitis (EAE), and may contribute to...
10.
Sarkar A, Kim K, Tsymbalyuk O, Keledjian K, Wilhelmy B, Sherani N, et al.
Ther Hypothermia Temp Manag
. 2022 Jun;
12(2):90-102.
PMID: 35675523
Spinal cord injury (SCI) is a devastating neurological condition with no effective treatment. Hypothermia induced by physical means (cold fluid) is established as an effective therapy in animal models of...