J Marc Simard
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Explore the profile of J Marc Simard including associated specialties, affiliations and a list of published articles.
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240
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6695
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Recent Articles
1.
Moyer M, Langbein J, Tsymbalyuk O, McAfee D, Chen C, Bachani M, et al.
bioRxiv
. 2025 Feb;
PMID: 39975103
Objective: Pentylenetetrazol (PTZ) kindling is a widely used model for inducing epileptogenesis and evaluating long-term seizure susceptibility differences among animals. This model is typically performed by chronic, repetitive exposures to...
2.
Shim B, Ciryam P, Tosun C, Serra R, Tsymbalyuk N, Keledjian K, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39796165
Brain ischemia causes disruption in cerebral blood flow and blood-brain barrier integrity, which are normally maintained by astrocyte endfeet. Emerging evidence points to dysregulation of the astrocyte translatome during ischemia,...
3.
Sheth K, Albers G, Saver J, Campbell B, Molyneaux B, Hinson H, et al.
Lancet Neurol
. 2024 Nov;
23(12):1205-1213.
PMID: 39577921
Background: No treatment is available to prevent brain oedema, which can occur after a large hemispheric infarction. Glibenclamide has previously been shown to improve functional outcome and reduce neurological or...
4.
Kardon A, Kim D, Ren H, Jaffa M, Elsaesser D, Armahizer M, et al.
Neurocrit Care
. 2024 Nov;
PMID: 39562388
Background: Corticosteroids are prescribed for refractory headache in patients with spontaneous subarachnoid hemorrhage (SAH) despite limited supporting evidence. We hypothesized that a short course of corticosteroids would reduce pain. Methods:...
5.
Zimmerman W, Pergakis M, Ahmad G, Morris N, Podell J, Chang W, et al.
Neurocrit Care
. 2024 Oct;
PMID: 39448427
Background: Patients with severe stroke are at high risk of secondary neurologic decline (ND) from the development of malignant cerebral edema (MCE). However, early infarcts are hard to diagnose on...
6.
Shim B, Ciryam P, Tosun C, Serra R, Tsymbalyuk N, Keledjian K, et al.
bioRxiv
. 2024 Oct;
PMID: 39416227
Brain ischemia causes disruption in cerebral blood flow and blood-brain barrier (BBB) integrity which are normally maintained by the astrocyte endfeet. Emerging evidence points to dysregulation of the astrocyte translatome...
7.
Wilhelmy B, Gerzanich V, Simard J, Stokum J
J Peripher Nerv Syst
. 2024 Oct;
29(4):555-566.
PMID: 39402795
Background And Aims: After peripheral nerve stretch injury, most degenerating axons are thought to become disconnected at the time of injury, referred to as primary axotomy. The possibility of secondary...
8.
Zhang C, Gerzanich V, Cruz-Cosme R, Zhang J, Tsymbalyuk O, Tosun C, et al.
mBio
. 2024 Sep;
15(11):e0230824.
PMID: 39345136
Importance: The major challenge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the pandemic is COVID-19-related mortality, which has tragically claimed millions of lives. COVID-19-associated morbidity and mortality...
9.
Simard J, Tosun C, Tsymbalyuk O, Moyer M, Keledjian K, Tsymbalyuk N, et al.
J Neurotrauma
. 2024 Sep;
42(1-2):143-160.
PMID: 39302058
Trauma to the brain can induce a contusion characterized by a discrete intracerebral or diffuse interstitial hemorrhage. In humans, "computed tomography-positive," that is, hemorrhagic, temporal lobe contusions (tlCont) have unique...
10.
Morris N, Simard J, Chaturvedi S
Neurology
. 2024 Jul;
103(4):e209714.
PMID: 39074339
The incidence of primary intracerebral hemorrhage (ICH) is increasing, particularly in younger patients, in part, because of increased prescription of anticoagulants. The ICH incidence rate from 2016 to 2018 in...