Karyn L Sheaffer
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Explore the profile of Karyn L Sheaffer including associated specialties, affiliations and a list of published articles.
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536
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Recent Articles
1.
Kim R, Sheaffer K, Choi I, Won K, Kaestner K
Genes Dev
. 2016 Nov;
30(21):2433-2442.
PMID: 27856615
Methylated cytosines are associated with gene silencing. The ten-eleven translocation (TET) hydroxylases, which oxidize methylated cytosines to 5-hydroxymethylcytosine (5hmC), are essential for cytosine demethylation. Gene silencing and activation are critical...
2.
Sheaffer K, Elliott E, Kaestner K
Cancer Prev Res (Phila)
. 2016 Feb;
9(7):534-46.
PMID: 26883721
Intestinal cancer is a heterogeneous disease driven by genetic mutations and epigenetic changes. Approximately 80% of sporadic colorectal cancers are initiated by mutation and inactivation of the adenomatous polyposis coli...
3.
Elliott E, Sheaffer K, Kaestner K
Elife
. 2016 Jan;
5.
PMID: 26808831
Dnmt1 is critical for immediate postnatal intestinal development, but is not required for the survival of the adult intestinal epithelium, the only rapidly dividing somatic tissue for which this has...
4.
Sheaffer K, Schug J
Methods Mol Biol
. 2016 Jan;
1402:101-117.
PMID: 26721486
Chromatin immunoprecipitation with massively parallel DNA sequencing (ChIP-Seq) has been used extensively to determine the genome-wide location of DNA-binding factors, such as transcription factors, posttranscriptionally modified histones, and members of...
5.
Bernstein D, Kameswaran V, Le Lay J, Sheaffer K, Kaestner K
Epigenetics Chromatin
. 2015 Aug;
8:27.
PMID: 26236400
Background: DNA methylation has emerged as an important regulator of development and disease, necessitating the design of more efficient and cost-effective methods for detecting and quantifying this epigenetic modification. Next-generation...
6.
Elliott E, Sheaffer K, Schug J, Stappenbeck T, Kaestner K
Development
. 2015 May;
142(12):2163-72.
PMID: 26023099
The DNA methyltransferase Dnmt1 maintains DNA methylation patterns and genomic stability in several in vitro cell systems. Ablation of Dnmt1 in mouse embryos causes death at the post-gastrulation stage; however,...
7.
Sheaffer K, Kim R, Aoki R, Elliott E, Schug J, Burger L, et al.
Genes Dev
. 2014 Mar;
28(6):652-64.
PMID: 24637118
The mammalian intestinal epithelium has a unique organization in which crypts harboring stem cells produce progenitors and finally clonal populations of differentiated cells. Remarkably, the epithelium is replaced every 3-5...
8.
Sheaffer K, Kaestner K
Cold Spring Harb Perspect Biol
. 2012 Sep;
4(9):a008284.
PMID: 22952394
The development of the gastrointestinal tract is a complex process that integrates signaling processes with downstream transcriptional responses. Here, we discuss the regionalization of the primitive gut and formation of...
9.
Zhong M, Niu W, Lu Z, Sarov M, Murray J, Janette J, et al.
PLoS Genet
. 2010 Feb;
6(2):e1000848.
PMID: 20174564
Transcription factors are key components of regulatory networks that control development, as well as the response to environmental stimuli. We have established an experimental pipeline in Caenorhabditis elegans that permits...
10.
Sheaffer K, Updike D, Mango S
Curr Biol
. 2008 Sep;
18(18):1355-64.
PMID: 18804378
Background: FoxA factors are critical regulators of embryonic development and postembryonic life, but little is know about the upstream pathways that modulate their activity. C. elegans pha-4 encodes a FoxA...