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Benita L McVicker

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Citations 507
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Recent Articles
1.
Kuracha M, Radhakrishna U, Kuracha S, Vegi N, Gurung J, McVicker B
Biomedicines . 2024 Nov; 12(11). PMID: 39595118
The pathway is highly evolved to maintain tissue homeostasis in diverse species by regulating cell proliferation, differentiation, and apoptosis. In tumor biology, the pathway is a prime example of signaling...
2.
Mitra R, Adhikari R, Davis S, McVicker B, Tuma P
Mol Biol Cell . 2024 Nov; 35(12):ar156. PMID: 39535899
Although peroxisomes are known to oxidize ethanol, metabolize lipids, and regulate oxidative stress, they remain understudied in the context of ethanol-induced liver injury. We examined peroxisome early responses to alcohol-induced...
3.
McVicker B, Simpson R, Hamel F, Bennett R
Biology (Basel) . 2023 Oct; 12(10). PMID: 37886997
Peroxisome-proliferator-activated receptor gamma (PPARγ) is a transcription factor with adipogenic, insulin-sensitizing, and antifibrotic properties. Strong PPARγ activators, such as the thiazolidinediones, can induce unwanted effects such as edema, weight gain,...
4.
Kuracha M, Govindarajan V, Loggie B, Tobi M, McVicker B
Int J Mol Sci . 2023 Aug; 24(15). PMID: 37569713
The phosphatidylinositol (PI3K)/AKT/mTOR axis represents an important therapeutic target to treat human cancers. A well-described downstream target of the PI3K pathway is the forkhead box O (FOXO) transcription factor family....
5.
Adhikari R, Mitra R, Bennett R, McVicker B, Tuma P
Hepatol Commun . 2023 Mar; 7(4). PMID: 36972397
Background: Chronic ethanol exposure leads to enhanced protein acetylation and acetaldehyde adduction. Of the multitude of proteins that are modified on ethanol administration, tubulin is among the best studied. However,...
6.
Zhang C, Hang Y, Tang W, Sil D, Jensen-Smith H, Bennett R, et al.
Pharmaceutics . 2022 Mar; 14(3). PMID: 35336043
Alcohol-associated liver disease (AALD) is a major cause of liver disorders worldwide. Current treatment options are limited, especially for AALD-associated fibrosis. Promising approaches include RNA interference for miR-155 overexpression in...
7.
Kuracha M, Thomas P, Tobi M, McVicker B
World J Gastroenterol . 2021 Dec; 27(41):7080-7099. PMID: 34887629
The aberrant use of alcohol is a major factor in cancer progression and metastasis. Contributing mechanisms include the systemic effects of alcohol and the exchange of bioactive molecules between cancerous...
8.
Rasineni K, Lee S, McVicker B, Osna N, Casey C, Kharbanda K
Biology (Basel) . 2021 Jan; 10(1). PMID: 33396223
Background: Work from our laboratory has shown that the ethanol-induced increase in apoptotic hepatocellular death is closely related to the impairment in the ability of the asialoglycoprotein receptor (ASGP-R) to...
9.
McVicker B, Hamel F, Simpson R, Bennett R
Biology (Basel) . 2020 Jul; 9(7). PMID: 32630819
Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal...
10.
McVicker B, Bennett R
Front Pharmacol . 2017 Jun; 8:318. PMID: 28620300
Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of...