Kartini Iskandar
Overview
Explore the profile of Kartini Iskandar including associated specialties, affiliations and a list of published articles.
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6
Citations
57
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Recent Articles
1.
Iskandar K, Foo J, Liew A, Zhu H, Raman D, Hirpara J, et al.
Autophagy
. 2024 Jan;
20(6):1418-1441.
PMID: 38261660
RAS is one of the most commonly mutated oncogenes associated with multiple cancer hallmarks. Notably, RAS activation induces intracellular reactive oxygen species (ROS) generation, which we previously demonstrated as a...
2.
Chong S, Iskandar K, Lai J, Qu J, Raman D, Valentin R, et al.
Nucleic Acids Res
. 2020 Nov;
48(22):12727-12745.
PMID: 33245769
Bcl-2 phosphorylation at serine-70 (S70pBcl2) confers resistance against drug-induced apoptosis. Nevertheless, its specific mechanism in driving drug-resistance remains unclear. We present evidence that S70pBcl2 promotes cancer cell survival by acting...
3.
Wang B, Bellot G, Iskandar K, Chong T, Goh F, Tai J, et al.
Sci Rep
. 2020 Nov;
10(1):18837.
PMID: 33139717
Sepsis is a potentially fatal condition triggered by systemic inflammatory response to infection. Due to the heightened immune reactivity and multi-organ pathology, treatment options are limited and several clinical trials...
4.
Raman D, Chong S, Iskandar K, Hirpara J, Pervaiz S
Redox Biol
. 2020 Jun;
34:101587.
PMID: 32512497
Stabilization of c-Myc oncoprotein is dependent on post-translational modifications, especially its phosphorylation at serine-62 (S62), which enhances its tumorigenic potential. Herein we report that increase in intracellular superoxide induces phospho-stabilization...
5.
Iskandar K, Rezlan M, Yadav S, Foo C, Sethi G, Qiang Y, et al.
Antioxid Redox Signal
. 2015 Dec;
24(14):781-94.
PMID: 26714745
Aims: We recently reported the death-inducing activity of a small-molecule compound, C1, which triggered reactive oxygen species (ROS)-dependent autophagy-associated apoptosis in a variety of human cancer cell lines. In this...
6.
Iskandar K, Rezlan M, Pervaiz S
Free Radic Biol Med
. 2015 Oct;
75 Suppl 1:S13.
PMID: 26461287
Reactive oxygen species (ROS) play a critical role in a variety of cellular processes, ranging from cell survival and proliferation to cell death. Previously, we reported the ability of a...