Jayshree L Hirpara
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Explore the profile of Jayshree L Hirpara including associated specialties, affiliations and a list of published articles.
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23
Citations
527
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Recent Articles
1.
Amali A, Paramasivam K, Huang C, Joshi A, Hirpara J, Ravikumar S, et al.
Front Immunol
. 2024 Sep;
15:1423086.
PMID: 39224595
Molecular chaperons stabilize protein folding and play a vital role in maintaining tissue homeostasis. To this intent, mitochondrial molecular chaperons may be involved in the regulation of oxidative phosphorylation and...
2.
Lee B, Chuah Y, Yoon J, Grinchuk O, Liang Y, Hirpara J, et al.
Cell Death Dis
. 2024 Jul;
15(7):547.
PMID: 39085240
No abstract available.
3.
Lee B, Chuah Y, Yoon J, Grinchuk O, Liang Y, Hirpara J, et al.
Cell Death Dis
. 2024 May;
15(5):338.
PMID: 38744809
Epitranscriptomic RNA modifications are crucial for the maintenance of glioma stem cells (GSCs), the most malignant cells in glioblastoma (GBM). 3-methylcytosine (mC) is a new epitranscriptomic mark on RNAs and...
4.
Iskandar K, Foo J, Liew A, Zhu H, Raman D, Hirpara J, et al.
Autophagy
. 2024 Jan;
20(6):1418-1441.
PMID: 38261660
RAS is one of the most commonly mutated oncogenes associated with multiple cancer hallmarks. Notably, RAS activation induces intracellular reactive oxygen species (ROS) generation, which we previously demonstrated as a...
5.
Lee S, Hirpara J, Qu J, Yadav S, Sachaphibulkij K, Pervaiz S
Cancer Lett
. 2021 Nov;
526:284-303.
PMID: 34843865
We report a novel topoisomerase IIα inhibitor, mercaptopyridine oxide (MPO), which induces G2/M arrest and senescence with distinctly different cell cycle regulators (p21 or p14) in HCT116p 53 and HCT116...
6.
Raman D, Tay P, Hirpara J, Liu D, Pervaiz S
Redox Biol
. 2021 Nov;
48:102193.
PMID: 34839142
Aims: Preferential expression of receptors for TNF-family related apoptosis inducing ligand (TRAIL), DR4 and DR5 makes TRAIL an attractive anti-cancer therapeutic. However, the efficacy of targeting death receptors has not...
7.
Foo B, Eu J, Hirpara J, Pervaiz S
Oxid Med Cell Longev
. 2021 Nov;
2021:1341604.
PMID: 34777681
Mitochondria are the main powerhouse of the cell, generating ATP through the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular processes. In addition to their role...
8.
Ramu D, Shan T, Hirpara J, Pervaiz S
IUBMB Life
. 2021 Mar;
73(3):530-542.
PMID: 33675120
The process of carcinogenesis and its progression involves an intricate interplay between a number of signaling networks, metabolic pathways and the microenvironment. These include an alteration in the cellular redox...
9.
Raman D, Chong S, Iskandar K, Hirpara J, Pervaiz S
Redox Biol
. 2020 Jun;
34:101587.
PMID: 32512497
Stabilization of c-Myc oncoprotein is dependent on post-translational modifications, especially its phosphorylation at serine-62 (S62), which enhances its tumorigenic potential. Herein we report that increase in intracellular superoxide induces phospho-stabilization...
10.
Hirpara J, Subramaniam K, Bellot G, Qu J, Seah S, Loh T, et al.
Redox Biol
. 2020 Jan;
30:101403.
PMID: 31954371
The death inhibitory proteins, cFLIP and Bcl-2, canonically act at different steps to regulate receptor-mediated apoptosis in cancer cells. Here we report that pharmacological or genetic means to effect an...