Karl T Riabowol
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Explore the profile of Karl T Riabowol including associated specialties, affiliations and a list of published articles.
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10
Citations
208
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Recent Articles
1.
McClurg U, McCracken S, Butler L, Riabowol K, Binda O
Bio Protoc
. 2018 Dec;
8(21).
PMID: 30515449
To assess oncogenic potential, classical transformation assays are based on cell line models. However, cell line based models do not reflect the complexity of human tissues. We thus developed an...
2.
McClurg U, Chit N, Azizyan M, Edwards J, Nabbi A, Riabowol K, et al.
Oncogene
. 2018 May;
37(34):4679-4691.
PMID: 29755129
The TP53-MDM2-AR-AKT signalling network plays a critical role in the development and progression of prostate cancer. However, the molecular mechanisms regulating this signalling network are not completely defined. By conducting...
3.
McClurg U, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, et al.
Br J Cancer
. 2018 Jan;
118(5):713-726.
PMID: 29381681
Background: Although the founding members of the INhibitor of Growth (ING) family of histone mark readers, ING1 and ING2, were defined as tumour suppressors in animal models, the role of...
4.
Nabbi A, McClurg U, Thalappilly S, Almami A, Mobahat M, Bismar T, et al.
BMC Med
. 2017 May;
15(1):103.
PMID: 28511652
Background: The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth...
5.
Bose P, Thakur S, Brockton N, Klimowicz A, Kornaga E, Nakoneshny S, et al.
Oncotarget
. 2014 Jun;
5(10):3210-9.
PMID: 24912621
The ING1 epigenetic regulator and tumor suppressor plays a central role in apoptosis. The Ing1 gene is functionally inactivated in many cancer types but is rarely mutated. Although most studies...
6.
Tallen U, Truss M, Kunitz F, Wellmann S, Unryn B, Sinn B, et al.
J Neurooncol
. 2007 Sep;
86(1):23-30.
PMID: 17763999
Impaired tumor suppressor functions, such as deficient p53, are characteristic for glioblastoma multiforme (GBM) and can cause resistance to DNA-damaging agents like cisplatin. We have recently shown that the INhibitor...
7.
Unryn B, Hao D, Gluck S, Riabowol K
Clin Cancer Res
. 2006 Nov;
12(21):6345-50.
PMID: 17085644
Purpose: Chronic viral infection and combinations of chemotherapeutic drugs have been reported to accelerate telomere erosion. Here, we asked if chemoradiotherapy, using the single agent cisplatin, would accelerate telomere loss...
8.
Unryn B, Cook L, Riabowol K
Aging Cell
. 2005 Mar;
4(2):97-101.
PMID: 15771613
Telomere length is linked to age-associated diseases, with shorter telomeres in blood associated with an increased probability of mortality from infection or heart disease. Little is known about how human...
9.
Quarrie J, Riabowol K
Sci Aging Knowledge Environ
. 2004 Aug;
2004(31):re5.
PMID: 15295107
Mice are excellent experimental models for genetic research and are being used to investigate the genetic component of organismal aging. Several mutant mice are known to possess defects in the...
10.
Berardi P, Meyyappan M, Riabowol K
J Biol Chem
. 2002 Dec;
278(9):7510-9.
PMID: 12464605
Senescent human diploid fibroblasts are unable to initiate DNA synthesis following mitogenic stimulation and adopt a unique gene expression profile distinct from young or quiescent cells. In this study, a...