Karl Sward
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Explore the profile of Karl Sward including associated specialties, affiliations and a list of published articles.
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104
Citations
4527
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Recent Articles
1.
Rippe C, Bastrup J, Holmberg J, Kawka K, Martinez M, Albinsson S, et al.
J Biol Chem
. 2025 Mar;
:108400.
PMID: 40081573
Age is a critical determinant of arterial disease, including aneurysm formation. Here, to understand the impact of aging on the arterial transcriptome, we leveraged RNA-sequencing data to define transcripts that...
2.
Kha M, Magnusson Y, Johansson I, Altiparmak G, Lundgren J, Nystrom J, et al.
Am J Pathol
. 2025 Feb;
PMID: 39954965
Recent studies have demonstrated that the transcription factor hepatocyte nuclear factor 4α (HNF4A) drives epithelial differentiation in the renal proximal tubules (PTs) and is critical for maintaining a mature PT...
3.
Bankell E, Liu L, van der Horst J, Rippe C, Jepps T, Nilsson B, et al.
Sci Rep
. 2024 Jun;
14(1):13321.
PMID: 38858497
Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and MRTF-B/MRTFB) suppress production of pro-inflammatory cytokines and chemokines in human smooth muscle cells (SMCs) through sequestration of RelA in the NF-κB complex, but...
4.
Liu L, Arevalo-Martinez M, Rippe C, Johansson M, Holmberg J, Albinsson S, et al.
Am J Physiol Cell Physiol
. 2023 Nov;
325(6):C1485-C1501.
PMID: 37927241
A role of Yes1-associated transcriptional regulator (YAP) and WW domain-containing transcription regulator 1 (TAZ) in vascular and gastrointestinal contractility due to control of myocardin (Myocd) expression, which in turn activates...
5.
Martinez M, Ritsvall O, Bastrup J, Celik S, Jakobsson G, Daoud F, et al.
JCI Insight
. 2023 Aug;
8(17).
PMID: 37561588
Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle...
6.
Nunez-Diaz C, Poceviciute D, Schultz N, Welinder C, Sward K, Wennstrom M
Mol Brain
. 2023 Feb;
16(1):25.
PMID: 36793056
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for...
7.
De Luca F, Kha M, Sward K, Johansson M
PLoS One
. 2023 Jan;
18(1):e0280270.
PMID: 36649229
The podocyte is a specialized cell type critically involved in maintaining the selective filtration barrier of the kidney. Podocytes are primary or secondary targets for a multitude of kidney diseases....
8.
Kha M, Krawczyk K, Choong O, De Luca F, Altiparmak G, Kallberg E, et al.
Am J Physiol Renal Physiol
. 2022 Dec;
324(1):F75-F90.
PMID: 36454702
Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of...
9.
Daoud F, Martinez M, Holst J, Holmberg J, Albinsson S, Sward K
Biochem Pharmacol
. 2022 Oct;
206:115307.
PMID: 36270325
A ruptured arterial aneurysm, especially in the aorta, represents one of the most acute and mortal conditions encountered in clinical medicine. Population-based screening in elderly men, treatment of risk factors,...
10.
Liu L, Kryvokhyzha D, Rippe C, Jacob A, Borreguero-Munoz A, Stenkula K, et al.
Cell Mol Life Sci
. 2022 Aug;
79(8):459.
PMID: 35913515
Differentiation of smooth muscle cells (SMCs) depends on serum response factor (SRF) and its co-activator myocardin (MYOCD). The role of MYOCD for the SMC program of gene transcription is well...