Karl Sward
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Explore the profile of Karl Sward including associated specialties, affiliations and a list of published articles.
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104
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4527
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Recent Articles
11.
Daoud F, Martinez M, Holmberg J, Alajbegovic A, Ali N, Rippe C, et al.
Arterioscler Thromb Vasc Biol
. 2022 Feb;
42(4):428-443.
PMID: 35196875
Background: Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. We hypothesize that appropriate mechanotransduction and contractile function in vascular smooth muscle...
12.
Bankell E, Liu X, Lundqvist M, Svensson D, Sward K, Sparr E, et al.
Biochem Biophys Rep
. 2022 Jan;
29:101192.
PMID: 34988298
The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported. Here, we demonstrate that...
13.
Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors
Liu L, Bankell E, Rippe C, Moren B, Stenkula K, Nilsson B, et al.
Front Physiol
. 2021 Oct;
12:732564.
PMID: 34671275
Myocardin related transcription factors (MRTFs: MYOCD/myocardin, MRTF-A, and MRTF-B) play a key role in smooth muscle cell differentiation by activating contractile genes. In atherosclerosis, MRTF levels change, and most notable...
14.
Liu L, Rippe C, Hansson O, Kryvokhyzha D, Fisher S, Ekman M, et al.
Front Physiol
. 2021 Sep;
12:710968.
PMID: 34539433
Myocardin-related transcription factors (MRTFs: myocardin/, MRTF-A/, and MRTF-B/) are co-factors of serum response factor (SRF) that activate the smooth muscle cell (SMC) gene program and that play roles in cardiovascular...
15.
Tutzauer J, Gonzalez de Valdivia E, Sward K, Alexandrakis Eilard I, Broselid S, Kahn R, et al.
Mol Pharmacol
. 2021 Jul;
100(3):271-282.
PMID: 34330822
G protein-coupled receptor 30 (GPR30) is a membrane receptor reported to bind 17-estradiol (E2) and mediate rapid nongenomic estrogen responses, hence also named G protein-coupled estrogen receptor. G-1 is a...
16.
Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, et al.
Eur Heart J
. 2021 Jul;
42(43):4481-4492.
PMID: 34297830
Aims: Cardiac injury and remodelling are associated with the rearrangement of cardiac lipids. Glycosphingolipids are membrane lipids that are important for cellular structure and function, and cardiac dysfunction is a...
17.
Rippe C, Moren B, Liu L, Stenkula K, Mustaniemi J, Wennstrom M, et al.
Sci Rep
. 2021 Mar;
11(1):5955.
PMID: 33727640
The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2) and serum response factor (SRF). Using a bioinformatics...
18.
Alajbegovic A, Holmberg J, Daoud F, Rippe C, Kalliokoski G, Ekman M, et al.
Vascul Pharmacol
. 2021 Jan;
138:106837.
PMID: 33516965
Objective: Smooth muscle cells contribute significantly to lipid-laden foam cells in atherosclerotic plaques. However, the underlying mechanisms transforming smooth muscle cells into foam cells are poorly understood. The purpose of...
19.
De Santis M, Alsafadi H, Tas S, Bolukbas D, Prithiviraj S, Da Silva I, et al.
Adv Mater
. 2020 Dec;
33(3):e2005476.
PMID: 33300242
Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant for human tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries remain unidentified. Here,...
20.
Daoud F, Holmberg J, Alajbegovic A, Grossi M, Rippe C, Sward K, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Sep;
11(2):623-637.
PMID: 32992050
Background & Aims: YAP (Yap1) and TAZ (Wwtr1) are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and cancer pathogenesis. Genetic...