Karl H Plate
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Explore the profile of Karl H Plate including associated specialties, affiliations and a list of published articles.
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88
Citations
5522
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Recent Articles
1.
Onay M, Harter P, Weber K, Piiper A, Czabanka M, Plate K, et al.
Biomedicines
. 2025 Jan;
12(12.
PMID: 39767775
Background: Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy, often associated with hippocampal sclerosis (HS), which involves selective neuronal loss in the Cornu Ammonis subregion 1...
2.
Cakmak P, Jurmeister P, Dive I, Zeiner P, Steinbach J, Fenton T, et al.
Clin Epigenetics
. 2024 Dec;
16(1):179.
PMID: 39663543
Background: Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-type adult-type glioblastoma with notable enlarged mono- or multinuclear tumor cells. While some studies suggest a...
3.
Laub V, Nan E, Elias L, Donaldson I, Bentsen M, Rusling L, et al.
Nucleic Acids Res
. 2024 Oct;
52(20):12262-12280.
PMID: 39377397
Developmental transcription factors act in networks, but how these networks achieve cell- and tissue specificity is still poorly understood. Here, we explored pre-B cell leukemia homeobox 1 (PBX1) in adult...
4.
Roesler J, Spitzer D, Jia X, Aasen S, Sommer K, Roller B, et al.
Neuro Oncol
. 2024 Jun;
26(11):2084-2099.
PMID: 38831719
Background: Brain metastases (BM) constitute an increasing challenge in oncology due to their impact on neurological function, limited treatment options, and poor prognosis. BM occurs through extravasation of circulating tumor...
5.
Yalcin B, Macas J, Wiercinska E, Harter P, Fawaz M, Schmachtel T, et al.
Cells
. 2023 Dec;
12(23).
PMID: 38067194
The bone marrow (BM) hematopoietic system (HS) gives rise to blood cells originating from hematopoietic stem cells (HSCs), including megakaryocytes (MKs) and red blood cells (erythrocytes; RBCs). Many steps of...
6.
Schmid K, Sehring J, Nemeth A, Harter P, Weber K, Vengadeswaran A, et al.
Brain Pathol
. 2023 Nov;
34(3):e13228.
PMID: 38012085
The current state-of-the-art analysis of central nervous system (CNS) tumors through DNA methylation profiling relies on the tumor classifier developed by Capper and colleagues, which centrally harnesses DNA methylation data...
7.
Picard D, Felsberg J, Langini M, Stachura P, Qin N, Macas J, et al.
Acta Neuropathol
. 2023 Sep;
146(4):551-564.
PMID: 37656187
Pilocytic astrocytoma (PA), the most common pediatric brain tumor, is driven by aberrant mitogen-activated protein kinase signaling most commonly caused by BRAF gene fusions or activating mutations. While 5-year overall...
8.
Sharma G, Braga M, Da Pieve C, Szopa W, Starzetz T, Plate K, et al.
Cancers (Basel)
. 2023 Jun;
15(12).
PMID: 37370741
There is no established method to assess the PD-L1 expression in brain tumours. Therefore, we investigated the suitability of affibody molecule (Z) radiolabelled with F-18 (AlF) and Ga-68 to measure...
9.
Burger M, Forster M, Romanski A, Strassheimer F, Macas J, Zeiner P, et al.
Neuro Oncol
. 2023 May;
25(11):2058-2071.
PMID: 37148198
Background: Glioblastoma (GB) is incurable at present without established treatment options for recurrent disease. In this phase I first-in-human clinical trial we investigated safety and feasibility of adoptive transfer of...
10.
Spitzer D, Khel M, Putz T, Zinke J, Jia X, Sommer K, et al.
Nat Protoc
. 2023 Mar;
18(5):1510-1542.
PMID: 36859615
The neurovascular unit (NVU), composed of endothelial cells, pericytes, juxtaposed astrocytes and microglia together with neurons, is essential for proper central nervous system functioning. The NVU critically regulates blood-brain barrier...