Karl Anker Jorgensen
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Explore the profile of Karl Anker Jorgensen including associated specialties, affiliations and a list of published articles.
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284
Citations
2455
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Recent Articles
1.
Barlose C, Bitsch R, Faghtmann J, Escobar C, Casacchia M, Kristensen A, et al.
J Am Chem Soc
. 2024 Nov;
146(49):34231-34251.
PMID: 39609771
A mechanistic investigation into the novel combination of the -halogen effect with enantioselective aminocatalysis unravels the mechanistic intricacies of [6 + 4] and [10 + 6] higher-order cycloadditions and the...
2.
Faghtmann J, Pladsbjerg Andresen S, Rask Ostergaard A, Anker Jorgensen K
Chemistry
. 2024 Oct;
31(1):e202403656.
PMID: 39469879
Cycloadditions are widely accepted as a group of reactions that rapidly generate molecular complexity. Being highly atom economic and often predictable, these reactions can generate up to four stereogenic centers...
3.
Obregon E, Rost L, Kocemba I, Kristensen A, McLeod D, Anker Jorgensen K
Angew Chem Int Ed Engl
. 2024 Jul;
63(42):e202410524.
PMID: 39007180
The substituted tetrahydrofuran core is a structural motif in many biologically active and natural compounds. However, the scarcity of enantioselective methods developed towards its synthesis makes this field challenging and...
4.
Waser P, Faghtmann J, Gil-Ordonez M, Kristensen A, Svenningsen E, Poulsen T, et al.
Chemistry
. 2024 Apr;
30(38):e202401354.
PMID: 38629389
A novel strategy that combines oxidative aminocatalysis and gold catalysis allows the preparation of chiral α-quaternary isochromanes, a motif that is prevalent in natural products and synthetic bioactive compounds. In...
5.
Faghtmann J, Eugui M, Nygaard Lamhauge J, Pladsbjerg Andresen S, Rask Ostergaard A, Bjerregaard Svenningsen E, et al.
Chemistry
. 2024 Apr;
30(32):e202401156.
PMID: 38564298
A novel cascade reaction initiated by an enantioselective aminocatalysed 1,3-dipolar [6+4] cycloaddition between catalytically generated trienamines and 3-oxidopyridinium betaines is presented. The [6+4] cycloadduct spontaneously undergoes an intramolecular enamine-mediated aldol,...
6.
Barlose C, Faghtmann J, Kaasik M, Mastroddi R, Anker Jorgensen K
Org Lett
. 2024 Feb;
26(8):1539-1543.
PMID: 38364106
An efficient strategy to obtain a broad array of chiral and achiral heterotropones and their corresponding [4 + 2] cycloadducts is disclosed. This strategy enables access to unique heterotropones and...
7.
Kaasik M, Chen P, Ricko S, Anker Jorgensen K, Houk K
J Am Chem Soc
. 2023 Oct;
145(43):23874-23890.
PMID: 37862136
Novel asymmetric aminocatalytic cycloadditions are described between formyl cycloheptatrienes and 6,6-dimethylfulvene that lead to [4 + 2], [6 + 2], and [4 + 6] cycloadducts. The unprecedented reaction course is...
8.
Inunnguaq Jessen N, Izzo J, Modlinski M, Bertuzzi G, Anker Jorgensen K
Chemistry
. 2023 Oct;
29(72):e202303299.
PMID: 37851861
The development of higher-order cycloadditions has mainly been restricted by the requisite usage of highly conjugated and reactive π-systems. Recent years have witnessed organocatalysis as a potent mediator for several...
9.
Ricko S, Bitsch R, Kaasik M, Otevrel J, Hojgaard Madsen M, Keimer A, et al.
J Am Chem Soc
. 2023 Sep;
145(38):20913-20926.
PMID: 37753541
This study presents a novel photoredox-enabled enantioconvergent catalytic strategy used to construct chiral 2-1,3-benzoxazines via an unprecedented oxa-6π electrocyclization utilizing racemic α-substituted glycinates as substrates. The approach leverages a cobalt-based...
10.
Lamhauge J, McLeod D, Barlose C, Oliver G, Viborg L, Warburg T, et al.
Chemistry
. 2023 Jun;
29(49):e202301830.
PMID: 37318111
Tropane alkaloids constitute a compound-class which is structurally defined by a central 8-azabicyclo[3.2.1]octane core. A diverse bioactivity profile combined with an unusual aza-bridged bicyclic framework has made tropanes molecules-of-interest within...