Karl A Walter
Overview
Explore the profile of Karl A Walter including associated specialties, affiliations and a list of published articles.
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13
Citations
321
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Recent Articles
1.
Yu X, Conyne M, Lake M, Walter K, Min J
MAbs
. 2022 Mar;
14(1):2044977.
PMID: 35275041
N-terminal heterogeneity resulting from non-uniform signal peptide (SP) cleavage can potentially affect biologics property attributes and result in extended product development timelines. Few studies are available on engineering SPs systematically...
2.
DiGiammarino E, Harlan J, Walter K, Ladror U, Edalji R, Hutchins C, et al.
MAbs
. 2011 Aug;
3(5):487-94.
PMID: 21814039
The DVD-Ig (TM) protein is a dual-specific immunoglobulin. Each of the two arms of the molecule contains two variable domains, an inner variable domain and an outer variable domain linked...
3.
Korepanova A, Pereda-Lopez A, Solomon L, Walter K, Lake M, Bianchi B, et al.
Protein Expr Purif
. 2009 Jan;
65(1):38-50.
PMID: 19121396
TRPV1 is a ligand-gated cation channel that is involved in acute thermal nociception and neurogenic inflammation. By using the GP67 signal peptide, high levels of full-length human TRPV1 was expressed...
4.
Huth J, Song D, Mendoza R, Black-Schaefer C, Mack J, Dorwin S, et al.
Chem Res Toxicol
. 2007 Nov;
20(12):1752-9.
PMID: 18001056
We have recently reported on the development of a La assay to detect reactive molecules by nuclear magnetic resonance (ALARM NMR) to detect reactive false positive hits from high-throughput screening,...
5.
Huth J, Park C, Petros A, Kunzer A, Wendt M, Wang X, et al.
Chem Biol Drug Des
. 2007 Jul;
70(1):1-12.
PMID: 17630989
The molecular chaperone HSP90 has been shown to facilitate cancer cell survival by stabilizing key proteins responsible for a malignant phenotype. We report here the results of parallel fragment-based drug...
6.
Lerner C, Hajduk P, Wagner R, Wagenaar F, Woodall C, Gu Y, et al.
Chem Biol Drug Des
. 2007 Jun;
69(6):395-404.
PMID: 17581233
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein...
7.
Sun C, Song D, Davis-Taber R, Barrett L, Scott V, Richardson P, et al.
Proc Natl Acad Sci U S A
. 2007 May;
104(19):7875-80.
PMID: 17470806
The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor that contributes to many different cellular functions including neurotransmission, neuronal survival, and synaptic plasticity. The solution...
8.
Niforatos W, Zhang X, Lake M, Walter K, Neelands T, Holzman T, et al.
Mol Pharmacol
. 2007 Feb;
71(5):1209-16.
PMID: 17314320
As a member of the transient receptor potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in nociceptive function and pain states. The endogenous ligands that...
9.
Stewart K, Steffy K, Harris K, Harlan J, Stoll V, Huth J, et al.
J Comput Aided Mol Des
. 2007 Feb;
21(1-3):121-30.
PMID: 17294246
Two new proteins of approximately 70 amino acids in length, corresponding to an unnaturally-linked N- and C-helix of the ectodomain of the gp41 protein from the human immunodeficiency virus (HIV)...
10.
Chen J, Lake M, Sabet R, Niforatos W, Pratt S, Cassar S, et al.
J Biomol Screen
. 2006 Nov;
12(1):61-9.
PMID: 17099245
Despite increasing use of cell-based assays in high-throughput screening (HTS) and lead optimization, one challenge is the adequate supply of high-quality cells expressing the target of interest. To this end,...