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Karim Bensaad

Explore the profile of Karim Bensaad including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 2179
Followers 0
Related Specialties
Oncology
Molecular Biology
Cell Biology
Top 10 Co-Authors
Adrian L Harris
Karen H Vousden
Francesca M Buffa
Esther Bridges
Christos E Zois
Thierry Soussi
Simon Wigfield
Morgane Le Bras
Ruth J Muschel
Masahiro Kawashima
Published In
Cancer Metab
Oncogene
Gene
Nat Med
EMBO J
Affiliations
Soon will be listed here.
Recent Articles
1.
Correction to: Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response
Yalaz C, Bridges E, Alham N, Zois C, Chen J, Bensaad K, et al.
Cancer Metab . 2025 Jan; 13(1):4. PMID: 39875986
No abstract available.
2.
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response
Yalaz C, Bridges E, Alham N, Zois C, Chen J, Bensaad K, et al.
Cancer Metab . 2024 Feb; 12(1):5. PMID: 38350962
Background: PDE6H encodes PDE6γ', the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied for its role in light transduction, increases...
3.
Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells
Kawashima M, Bensaad K, Zois C, Barberis A, Bridges E, Wigfield S, et al.
Cancer Metab . 2020 Aug; 8:18. PMID: 32789015
[This corrects the article DOI: 10.1186/s40170-020-00219-4.].
4.
Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells
Kawashima M, Bensaad K, Zois C, Barberis A, Bridges E, Wigfield S, et al.
Cancer Metab . 2020 Jul; 8:13. PMID: 32647572
Background: Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitochondrial inner...
5.
Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation
Bensaad K, Favaro E, Lewis C, Peck B, Lord S, Collins J, et al.
Cell Rep . 2014 Sep; 9(1):349-365. PMID: 25263561
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved...
6.
Cancer metabolism as a therapeutic target: metabolic synthetic lethality
Bensaad K, Harris A
Oncology (Williston Park) . 2014 Sep; 27(5):467, 473-4. PMID: 25184271
No abstract available.
7.
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
Griffiths B, Lewis C, Bensaad K, Ros S, Zhang Q, Ferber E, et al.
Cancer Metab . 2013 Nov; 1(1):3. PMID: 24280005
Background: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated...
8.
Hypoxia and metabolism in cancer
Bensaad K, Harris A
Adv Exp Med Biol . 2013 Nov; 772:1-39. PMID: 24272352
Interest in targeting metabolism has been renewed in recent years as research increases understanding of the altered metabolic profile of tumor cells compared with that of normal cells. Metabolic reprogramming...
9.
Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells
Favaro E, Bensaad K, Chong M, Tennant D, Ferguson D, Snell C, et al.
Cell Metab . 2012 Nov; 16(6):751-64. PMID: 23177934
Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment that can encourage these transformations. We report that glycogen...
10.
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival
Croft D, Crighton D, Samuel M, Lourenco F, Munro J, Wood J, et al.
Cell Res . 2010 Nov; 21(4):666-82. PMID: 21079653
The central arbiter of cell fate in response to DNA damage is p53, which regulates the expression of genes involved in cell cycle arrest, survival and apoptosis. Although many responses...