Karim-Jean Armache
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Explore the profile of Karim-Jean Armache including associated specialties, affiliations and a list of published articles.
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31
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1410
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Recent Articles
11.
Lee S, Abini-Agbomson S, Perry D, Goodman A, Rao B, Huang M, et al.
Nat Struct Mol Biol
. 2023 May;
30(7):891-901.
PMID: 37217653
Little is understood about how the two major types of heterochromatin domains (HP1 and Polycomb) are kept separate. In the yeast Cryptococcus neoformans, the Polycomb-like protein Ccc1 prevents deposition of...
12.
Abini-Agbomson S, Gretarsson K, Shih R, Hsieh L, Lou T, De Ioannes P, et al.
bioRxiv
. 2023 Mar;
PMID: 36993485
The intricate regulation of chromatin plays a key role in controlling genome architecture and accessibility. Histone lysine methyltransferases regulate chromatin by catalyzing the methylation of specific histone residues but are...
13.
Thomas J, Valencia-Sanchez M, Tamburri S, Gloor S, Rustichelli S, Godinez-Lopez V, et al.
bioRxiv
. 2023 Mar;
PMID: 36865140
One Sentence Summary: We reveal the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1.
14.
Bryson T, De Ioannes P, Valencia-Sanchez M, Henikoff J, Talbert P, Lee R, et al.
Mol Cell
. 2022 Nov;
82(23):4458-4470.e5.
PMID: 36370708
The two doublet histones of Marseillevirus are distantly related to the four eukaryotic core histones and wrap 121 base pairs of DNA to form remarkably similar nucleosomes. By permeabilizing Marseillevirus...
15.
Talbert P, Armache K, Henikoff S
Epigenetics Chromatin
. 2022 May;
15(1):21.
PMID: 35624484
The common histones H2A, H2B, H3, and H4 are the characteristic components of eukaryotic nucleosomes, which function to wrap DNA and compact the genome as well as to regulate access...
16.
Valencia-Sanchez M, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, et al.
Nat Struct Mol Biol
. 2021 Apr;
28(5):413-417.
PMID: 33927388
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic...
17.
Grau D, Zhang Y, Lee C, Valencia-Sanchez M, Zhang J, Wang M, et al.
Nat Commun
. 2021 Jan;
12(1):714.
PMID: 33514705
Polycomb repressive complex 2 (PRC2) is a histone methyltransferase critical for maintaining gene silencing during eukaryotic development. In mammals, PRC2 activity is regulated in part by the selective incorporation of...
18.
Valencia-Sanchez M, De Ioannes P, Wang M, Truong D, Lee R, Armache J, et al.
Science
. 2021 Jan;
371(6527).
PMID: 33479126
Dot1 (disruptor of telomeric silencing-1), the histone H3 lysine 79 (H3K79) methyltransferase, is conserved throughout evolution, and its deregulation is found in human leukemias. Here, we provide evidence that acetylation...
19.
Armache A, Yang S, Martinez de Paz A, Robbins L, Durmaz C, Cheong J, et al.
Nature
. 2020 Jul;
583(7818):852-857.
PMID: 32699416
Complex organisms can rapidly induce select genes in response to diverse environmental cues. This regulation occurs in the context of large genomes condensed by histone proteins into chromatin. The sensing...
20.
Alecki C, Chiwara V, Sanz L, Grau D, Arias Perez O, Boulier E, et al.
Nat Commun
. 2020 Apr;
11(1):1781.
PMID: 32286294
Polycomb Group (PcG) proteins form memory of transient transcriptional repression that is necessary for development. In Drosophila, DNA elements termed Polycomb Response Elements (PREs) recruit PcG proteins. How PcG activities...