Karen M J van Loo
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Explore the profile of Karen M J van Loo including associated specialties, affiliations and a list of published articles.
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37
Citations
328
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Recent Articles
21.
Woitecki A, Muller J, van Loo K, Sowade R, Becker A, Schoch S
J Neurosci
. 2016 Mar;
36(9):2561-70.
PMID: 26936998
Significance Statement: Aberrant synaptic activity is observed in many neurological disorders and has been suggested as an important factor contributing to the pathophysiology. Intriguingly, pathophysiologic activity can also trigger signaling...
22.
van Loo K, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, et al.
Nat Commun
. 2015 Oct;
6:8688.
PMID: 26498180
Temporal lobe epilepsy (TLE) is the most common focal seizure disorder in adults. In many patients, transient brain insults, including status epilepticus (SE), are followed by a latent period of...
23.
Kulbida R, Wang Y, Mandelkow E, Schoch S, Becker A, van Loo K
Brain Struct Funct
. 2014 Jun;
220(5):3067-73.
PMID: 24889163
Focal epilepsies often originate in the hippocampal formation of the temporal lobe (temporal lobe epilepsy) and are generally acquired after transient brain insults. Such insults induce cellular and structural reorganization...
24.
Pernhorst K, van Loo K, von Lehe M, Priebe L, Cichon S, Herms S, et al.
Brain Res
. 2013 Jan;
1499:136-44.
PMID: 23333373
Many brain disorders, including epilepsy, migraine and depression, manifest with episodic symptoms that may last for various time intervals. Transient alterations of neuronal function such as related to serotonin homeostasis...
25.
Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo K, Becker A, et al.
J Physiol
. 2012 Aug;
590(22):5895-905.
PMID: 22930274
Extracellular zinc can induce numerous acute and persistent physiological and toxic effects in neurons by acting at their plasma membrane or intracellularly following permeation or uptake into them. Zinc acutely...
26.
van Loo K, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, et al.
J Biol Chem
. 2012 Mar;
287(19):15489-501.
PMID: 22431737
The pore-forming Ca(2+) channel subunit Ca(V)3.2 mediates a low voltage-activated (T-type) Ca(2+) current (I(CaT)) that contributes pivotally to neuronal and cardiac pacemaker activity. Despite the importance of tightly regulated Ca(V)3.2...
27.
Pernhorst K, Raabe A, Niehusmann P, van Loo K, Grote A, Hoffmann P, et al.
J Neuropathol Exp Neurol
. 2011 Nov;
70(12):1080-8.
PMID: 22082659
The functional consequences of single nucleotide polymorphisms associated with episodic brain disorders such as epilepsy and depression are unclear. Allelic associations with generalized epilepsies have been reported for single nucleotide...
28.
Schijndel J, van Zweeden M, van Loo K, Djurovic S, Andreassen O, Hansen T, et al.
Psychiatr Genet
. 2011 Feb;
21(3):125-31.
PMID: 21317683
Objective: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of...
29.
Moons T, Claes S, Martens G, Peuskens J, van Loo K, Schijndel J, et al.
Schizophr Res
. 2010 Nov;
125(2-3):187-93.
PMID: 21050724
Context: In the healthy population, several pathways are known to exert an effect on basal metabolic factors. Previous studies have found associations between single nucleotide polymorphisms in clock genes or...
30.
Schijndel J, van Zweeden M, van Loo K, Lubbers L, Pesman G, Sweep F, et al.
Physiol Behav
. 2010 Nov;
102(2):121-5.
PMID: 21034754
A synergistic relationship is thought to exist between hypothalamic-pituitary-adrenal (HPA) axis activity and dopamine neurotransmission. To test whether a high response to dopamine indeed implies a hyperactive HPA-axis, we here...