Karen M J van Loo
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Explore the profile of Karen M J van Loo including associated specialties, affiliations and a list of published articles.
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37
Citations
328
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Recent Articles
11.
Cases-Cunillera S, van Loo K, Pitsch J, Quatraccioni A, Sivalingam S, Salomoni P, et al.
Neuro Oncol
. 2021 Dec;
24(5):741-754.
PMID: 34865163
Background: Developmental brain tumors harboring BRAFV600E somatic mutation are diverse. Here, we describe molecular factors that determine BRAFV600E-induced tumor biology and function. Methods: Intraventricular in utero electroporation in combination with...
12.
Tolve M, Ulusoy A, Patikas N, Islam K, Bodea G, Ozturk E, et al.
Cell Rep
. 2021 Sep;
36(11):109697.
PMID: 34525371
Midbrain dopaminergic (mDA) neurons are diverse in their projection targets, effect on behavior, and susceptibility to neurodegeneration. Little is known about the molecular mechanisms establishing this diversity during development. We...
13.
Schoch S, Quatraccioni A, Robens B, Maresch R, van Loo K, Cases-Cunillera S, et al.
J Neurosci
. 2021 Aug;
41(39):8111-8125.
PMID: 34400520
The size and structure of the dendritic arbor play important roles in determining how synaptic inputs of neurons are converted to action potential output. The regulatory mechanisms governing the development...
14.
Pitsch J, van Loo K, Gallus M, Dik A, Kamalizade D, Baumgart A, et al.
Ann Neurol
. 2020 Dec;
89(4):666-685.
PMID: 33368582
Objective: Limbic encephalitis (LE) comprises a spectrum of inflammatory changes in affected brain structures including the presence of autoantibodies and lymphoid cells. However, the potential of distinct lymphocyte subsets alone...
15.
Tsortouktzidis D, Schulz H, Hamed M, Vatter H, Surges R, Schoch S, et al.
Epilepsia
. 2020 Dec;
62(1):e29-e34.
PMID: 33319393
Increasing evidence indicates the pathogenetic relevance of regulatory genomic motifs for variability in the manifestation of brain disorders. In this context, cis-regulatory effects of single nucleotide polymorphisms (SNPs) on gene...
16.
Pensold D, Reichard J, van Loo K, Ciganok N, Hahn A, Bayer C, et al.
Cereb Cortex
. 2020 Mar;
30(7):3921-3937.
PMID: 32147726
The balance of excitation and inhibition is essential for cortical information processing, relying on the tight orchestration of the underlying subcellular processes. Dynamic transcriptional control by DNA methylation, catalyzed by...
17.
van Loo K, Becker A
Front Cell Neurosci
. 2020 Jan;
13:587.
PMID: 31992970
Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "" etiology or a symptomatic "" component. Genetic studies have revealed that many epilepsy susceptibility...
18.
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis
van Loo K, Rummel C, Pitsch J, Muller J, Bikbaev A, Martinez-Chavez E, et al.
J Neurosci
. 2019 Feb;
39(17):3175-3187.
PMID: 30792272
Transient brain insults, including status epilepticus (SE), can trigger a period of epileptogenesis during which functional and structural reorganization of neuronal networks occurs resulting in the onset of focal epileptic...
19.
Pitsch J, Kuehn J, Gnatkovsky V, Muller J, van Loo K, de Curtis M, et al.
Mol Neurobiol
. 2018 Jun;
56(3):1825-1840.
PMID: 29934763
Temporal lobe epilepsy (TLE) represents a devastating neurological condition, in which approximately 4/5 of patients remain refractory for anti-convulsive drugs. Epilepsy surgery biopsies often reveal the damage pattern of "hippocampal...
20.
Kostoula C, Pascente R, Ravizza T, McCown T, Schoch S, Vezzani A, et al.
Mol Neurobiol
. 2017 Jul;
55(5):4463-4472.
PMID: 28669125
Insights into the dynamic changes in molecular processes occurring in the brain during epileptogenesis can substantially improve our understanding of their pathogenetic relevance. In this context, neuroinflammation is a potential...