Karen L Edelblum
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Explore the profile of Karen L Edelblum including associated specialties, affiliations and a list of published articles.
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43
Citations
1193
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Recent Articles
1.
Fischer M, Jia L, Edelblum K
J Immunol
. 2024 Sep;
213(9):1380-1391.
PMID: 39311642
Intraepithelial lymphocytes (IELs) expressing the TCRγδ survey the intestinal epithelium to limit the invasion of microbial pathogens. The production of type I IFN is a central component of an antiviral...
2.
Chawla A, Vandereyken M, Arias M, Santiago L, Dikovskaya D, Nguyen C, et al.
Mucosal Immunol
. 2024 Aug;
17(6):1242-1255.
PMID: 39137883
Intestinal intraepithelial T lymphocytes (IEL) constitutively express high amounts of the cytotoxic proteases Granzymes (Gzm) A and B and are therefore thought to protect the intestinal epithelium against infection by...
3.
Fischer M, Jia L, Edelblum K
bioRxiv
. 2024 Apr;
PMID: 38559228
Intraepithelial lymphocytes (IEL) expressing the γδ T cell receptor (TCR) survey the intestinal epithelium to limit the invasion of microbial pathogens. The production of type I interferon (IFN) is a...
4.
Bandyopadhyay S, Zhang X, Ascura A, Edelblum K, Bonder E, Gao N
J Cell Physiol
. 2023 Oct;
239(1):36-50.
PMID: 37877586
Human enterocytes are primary targets of infection by invasive bacterium Salmonella Typhimurium, and studies using nonintestinal epithelial cells established that S. Typhimurium activates Rho family GTPases, primarily CDC42, to modulate...
5.
El Bissati K, Krishack P, Zhou Y, Weber C, Lykins J, Jankovic D, et al.
Vaccines (Basel)
. 2023 Sep;
11(9).
PMID: 37766162
CD4 T cells have been found to play critical roles in the control of both acute and chronic infection. Previous studies identified a protective role for the CD4 T cell-eliciting...
6.
Balasubramanian I, Bandyopadhyay S, Flores J, Bianchi-Smak J, Lin X, Liu H, et al.
EMBO J
. 2023 Sep;
42(21):e113975.
PMID: 37718683
Paneth cells (PCs), a specialized secretory cell type in the small intestine, are increasingly recognized as having an essential role in host responses to microbiome and environmental stresses. Whether and...
7.
Xu W, Bergsbaken T, Edelblum K
Am J Physiol Cell Physiol
. 2022 Aug;
323(4):C1161-C1167.
PMID: 36036450
Intestinal tissue-resident lymphocytes are critical for maintenance of the mucosal barrier and to prevent enteric infections. The activation of these lymphocytes must be tightly regulated to prevent aberrant inflammation and...
8.
El-Naccache D, Chen F, Palma M, Lemenze A, Fischer M, Wu W, et al.
Cell Rep
. 2022 Aug;
40(5):111150.
PMID: 35926464
Intestinal nematode parasites can cross the epithelial barrier, causing tissue damage and release of danger-associated molecular patterns (DAMPs) that may promote host protective type 2 immunity. We investigate whether adenosine...
9.
Fischer M, Edelblum K
Curr Protoc
. 2022 Aug;
2(8):e516.
PMID: 35926140
Intraepithelial lymphocytes (IELs) are critical sentinels involved in host defense and maintenance of the intestinal mucosal barrier. IELs expressing the γδ T-cell receptor provide continuous surveillance of the villous epithelium...
10.
Maldonado S, Dai J, Dutta O, Hurley H, Singh S, Gittens-Williams L, et al.
J Immunol
. 2022 Jul;
209(4):675-683.
PMID: 35879099
Plasmacytoid dendritic cells (pDCs) have been implicated as having a role in antifungal immunity, but mechanisms of their interaction with fungi and the resulting cellular responses are not well understood....