Karen Campos-Leon
Overview
Explore the profile of Karen Campos-Leon including associated specialties, affiliations and a list of published articles.
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6
Citations
79
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Recent Articles
1.
Campos-Leon K, Ferguson J, Gunther T, Wood C, Wingett S, Pekel S, et al.
PLoS Pathog
. 2025 Jan;
21(1):e1012506.
PMID: 39869645
Upon infection, human papillomavirus (HPV) manipulates host cell gene expression to create an environment that is supportive of a productive and persistent infection. The virus-induced changes to the host cell's...
2.
Borkosky S, Fassolari M, Campos-Leon K, Rossi A, Salgueiro M, Pascuale C, et al.
J Mol Biol
. 2022 Nov;
435(16):167889.
PMID: 36402224
p53 exerts its tumour suppressor activity by modulating hundreds of genes and it can also repress viral replication. Such is the case of human papillomavirus (HPV) through targeting the E2...
3.
Ferguson J, Campos-Leon K, Pentland I, Stockton J, Gunther T, Beggs A, et al.
PLoS Pathog
. 2021 Nov;
17(11):e1010032.
PMID: 34735550
The ubiquitous host protein, CCCTC-binding factor (CTCF), is an essential regulator of cellular transcription and functions to maintain epigenetic boundaries, stabilise chromatin loops and regulate splicing of alternative exons. We...
4.
Pentland I, Campos-Leon K, Cotic M, Davies K, Wood C, Groves I, et al.
PLoS Biol
. 2018 Oct;
16(10):e2005752.
PMID: 30359362
The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted. Upon epithelial differentiation, E6/E7 transcription...
5.
Campos-Leon K, Wijendra K, Siddiqa A, Pentland I, Feeney K, Knapman A, et al.
J Virol
. 2016 Dec;
91(5).
PMID: 28031358
Rad50-interacting protein 1 (Rint1) associates with the DNA damage response protein Rad50 during the transition from the S phase to the G/M phase and functions in radiation-induced G checkpoint control....
6.
Harris L, McFarlane-Majeed L, Campos-Leon K, Roberts S, Parish J
J Virol
. 2016 Nov;
91(1).
PMID: 27795438
Importance: Infections with high-risk human papillomaviruses (HPVs) are a major cause of anogenital and oropharyngeal cancers. During infection, the circular DNA genome of HPV persists within the nucleus, independently of...
7.
Brown C, Campos-Leon K, Strickland M, Williams C, Fairweather V, Brady R, et al.
Nucleic Acids Res
. 2010 Dec;
39(7):2969-80.
PMID: 21131281
Although DNA flexibility is known to play an important role in DNA-protein interactions, the importance of protein flexibility is less well understood. Here, we show that protein dynamics are important...