Karel Soucek
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Explore the profile of Karel Soucek including associated specialties, affiliations and a list of published articles.
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113
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1386
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Recent Articles
1.
Moyano P, Kubina T, Paruch S, Jaroskova A, Novotny J, Skockova V, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(1):e202412786.
PMID: 39503260
Protein kinases are key regulators of numerous biological processes and aberrant kinase activity can cause various diseases, particularly cancer. Herein, we report the identification of new series of highly selective...
2.
Ondrisova L, Seda V, Hlavac K, Pavelkova P, Hoferkova E, Chiodin G, et al.
J Clin Invest
. 2024 Oct;
134(23).
PMID: 39436708
Bruton tyrosine kinase (BTK) inhibitor therapy induces peripheral blood lymphocytosis in chronic lymphocytic leukemia (CLL), which lasts for several months. It remains unclear whether nongenetic adaptation mechanisms exist, allowing CLL...
3.
Valcikova B, Vadovicova N, Smolkova K, Zacpalova M, Krejci P, Lee S, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(44):e2321305121.
PMID: 39436655
The eIF4F translation initiation complex plays a critical role in melanoma resistance to clinical BRAF and MEK inhibitors. In this study, we uncover a function of eIF4F in the negative...
4.
Chrenkova E, Studentova H, Hola K, Kahounova Z, Hendrychova R, Soucek K, et al.
Front Oncol
. 2024 Sep;
14:1394292.
PMID: 39319053
Background: Prostate cancer is the second leading cause of male cancer-related deaths in Western countries, which is predominantly attributed to the metastatic castration-resistant stage of the disease (CRPC). There is...
5.
Drapela S, Kvokackova B, Slabakova E, Kotrbova A, Gomoryova K, Fedr R, et al.
Cell Oncol (Dordr)
. 2024 Aug;
48(1):205-218.
PMID: 39162992
Purpose: Docetaxel resistance is a significant obstacle in the treatment of prostate cancer (PCa), resulting in unfavorable patient prognoses. Intratumoral heterogeneity, often associated with epithelial-to-mesenchymal transition (EMT), has previously emerged...
6.
Prochazkova J, Fedr R, Hradilova B, Kvokackova B, Slavik J, Kovac O, et al.
J Lipid Res
. 2024 Jul;
65(9):100609.
PMID: 39084491
Glycosylated sphingolipids (GSLs) are a diverse group of cellular lipids typically reported as being rare in normal mammary tissue. In breast cancer (BCa), GSLs have emerged as noteworthy markers associated...
7.
Nemec V, Remes M, Benovsky P, Bock M, Srankova E, Wong J, et al.
J Med Chem
. 2024 Jul;
67(15):12632-12659.
PMID: 39023313
Activin receptor-like kinases 1-7 (ALK1-7) regulate a complex network of SMAD-independent as well as SMAD-dependent signaling pathways. One of the widely used inhibitors for functional investigations of these processes, in...
8.
Besse A, Sedlarikova L, Buechler L, Kraus M, Yang C, Strakova N, et al.
Br J Cancer
. 2024 Jul;
131(5):918-930.
PMID: 38969867
Background: Resistance to chemotherapy is a major problem in the treatment of patients with triple-negative breast cancer (TNBC). Preclinical data suggest that TNBC is dependent on proteasomes; however, clinical observations...
9.
Kahounova Z, Pickova M, Drapela S, Bouchal J, Szczyrbova E, Navratil J, et al.
Cell Death Dis
. 2024 Jul;
15(7):472.
PMID: 38956058
No abstract available.
10.
Pickova M, Kahounova Z, Radaszkiewicz T, Prochazkova J, Fedr R, Noskova M, et al.
Sci Rep
. 2024 Apr;
14(1):7827.
PMID: 38570556
Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can...